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Ritonavir Side Effects

The most commonly reported side effects of ritonavir include covid-19, disease recurrence, and dysgeusia, based on 98,355 FDA adverse event reports from 2004 to 2025.

Ritonavir side effects

Percentages show how often each reaction appears relative to total reports for ritonavir.

1
Covid-1923.4%23,054
2
Disease Recurrence20.5%20,144
3
Dysgeusia7.6%7,445
4
Diarrhoea5.1%5,013
5
Drug Interaction4.8%4,720
6
Nausea3.8%3,736
7
Off Label Use3.3%3,292
8
Foetal Exposure During Pregnancy3.3%3,249
9
Fatigue3.0%2,920
10
Pain2.9%2,871
11
Headache2.7%2,649
12
Vomiting2.3%2,252
13
Cough2.3%2,244
14
Anxiety2.2%2,139
15
Pyrexia1.9%1,838

These are voluntary reports and do not establish that ritonavir caused these reactions.

Report severity

51.6%Serious50,778 reports
18.7%Hospitalizations18,361 reports
5.6%Fatal5,470 reports

Seriousness is determined by the reporter, not by OpenClaim.

Ritonavir drug interactions

Other drugs that appear in adverse event reports alongside ritonavir. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Nirmatrelvir51.4%50,593
2
Tenofovir14.0%13,732
3
Lopinavir12.2%12,001
4
Lamivudine10.3%10,166
5
Emtricitabine10.3%10,090
6
Darunavir8.6%8,461
7
Atazanavir-sulfate7.5%7,420
8
Zidovudine6.4%6,311
9
Raltegravir-potassium4.8%4,693
10
Abacavir4.3%4,212
11
Efavirenz3.7%3,599
12
Didanosine2.1%2,086
13
Dolutegravir2.0%2,013
14
Nevirapine2.0%1,965
15
Stavudine1.9%1,825

Taken alongside

1
Tenofovir7.1%6,978
2
Lamivudine5.8%5,695
3
Emtricitabine5.7%5,607
4
Darunavir4.3%4,259
5
Lopinavir4.3%4,207
6
Acetaminophen3.4%3,360
7
Atazanavir-sulfate3.3%3,273
8
Atorvastatin-calcium3.3%3,215
9
Levothyroxine-sodium3.2%3,152
10
Abacavir2.9%2,888
11
Ergocalciferol2.9%2,842
12
Aspirin2.7%2,683
13
Sulfamethoxazole2.7%2,677
14
Zidovudine2.7%2,607
15
Trimethoprim2.5%2,420

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports ritonavir side effects

45.9% of ritonavir adverse event reports involve female patients and 41.5% involve male patients. The largest age group is adult at 66%. These figures reflect who reports side effects, not underlying risk.

Sex

Female45.9%
Male41.5%
Unknown12.5%

Age group

< 22.7%
2–110.5%
12–170.7%
18–6465.9%
65+30.2%

What is ritonavir used for

Conditions and purposes for which patients were taking ritonavir when the adverse event was reported.

Abdominal PainAccidental ExposureAccidental Exposure To ProductAcquired Immunodeficiency SyndromeAcute Hiv InfectionAcute Respiratory Distress SyndromeAcute Respiratory FailureAids Dementia ComplexAids Related ComplicationAids Related ComplicationAnaemiaAnti-infective TherapyAntibiotic ProphylaxisAntibiotic TherapyAntifungal Prophylaxis

Showing 15 of 424 indications

Ritonavir brand names and reporting trend

Ritonavir is sold under the brand name Lopinavir And Ritonavir.

Brand names

Lopinavir And Ritonavir19,436

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking ritonavir with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.