OpenClaim

Risedronate Side Effects

The most commonly reported side effects of risedronate include pain, arthralgia, and off label use, based on 34,581 FDA adverse event reports from 2004 to 2025. 10.4% of reports found the drug to be ineffective.

Risedronate side effects

Percentages show how often each reaction appears relative to total reports for risedronate.

1
Drug Ineffective10.4%3,602
2
Pain9.8%3,387
3
Arthralgia9.3%3,220
4
Off Label Use9.2%3,177
5
Fatigue7.8%2,681
6
Dyspnoea7.4%2,570
7
Nausea7.3%2,527
8
Diarrhoea7.1%2,449
9
Drug Hypersensitivity7.1%2,448
10
Vomiting7.1%2,443
11
Rheumatoid Arthritis7.0%2,419
12
Pneumonia6.8%2,349
13
Malaise6.3%2,170
14
Headache5.8%2,018
15
Joint Swelling5.7%1,972

These are voluntary reports and do not establish that risedronate caused these reactions.

Report severity

83.6%Serious28,921 reports
39.5%Hospitalizations13,670 reports
8.7%Fatal2,994 reports

Seriousness is determined by the reporter, not by OpenClaim.

Risedronate drug interactions

Other drugs that appear in adverse event reports alongside risedronate. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Rituximab15.0%5,181
2
Prednisone11.5%3,985
3
Adalimumab11.2%3,864
4
Methotrexate11.1%3,850
5
Etanercept10.3%3,577
6
Alendronate-sodium9.5%3,268
7
Tocilizumab9.3%3,208
8
Abatacept9.2%3,178
9
Infliximab8.8%3,056
10
Leflunomide8.0%2,755
11
Hydroxychloroquine-sulfate7.0%2,417
12
Sulfasalazine6.4%2,197
13
Certolizumab-pegol5.9%2,042
14
Golimumab5.8%2,018
15
Tofacitinib5.8%2,010

Taken alongside

1
Prednisone19.9%6,892
2
Acetaminophen19.0%6,586
3
Ergocalciferol16.6%5,725
4
Calcium15.8%5,470
5
Levothyroxine-sodium13.4%4,626
6
Folic-acid11.9%4,114
7
Pantoprazole-sodium11.7%4,050
8
Aspirin11.0%3,812
9
Methotrexate10.0%3,467
10
Atorvastatin-calcium7.9%2,717
11
Amlodipine7.6%2,638
12
Omeprazole7.3%2,538
13
Methylprednisolone7.1%2,463
14
Lansoprazole6.9%2,386
15
Furosemide6.9%2,371

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports risedronate side effects

77.9% of risedronate adverse event reports involve female patients and 13.6% involve male patients. The largest age group is elderly at 58%. These figures reflect who reports side effects, not underlying risk.

Sex

Female77.9%
Male13.6%
Unknown8.6%

Age group

< 2<0.1%
2–110.1%
12–170.1%
18–6442.1%
65+57.6%

What is risedronate used for

Conditions and purposes for which patients were taking risedronate when the adverse event was reported.

Adrenocortical Steroid TherapyAdverse Drug ReactionAllergic Granulomatous AngiitisAnaemiaAntiviral ProphylaxisArthralgiaArthritisArthropathyAstheniaAsthmaAtypical Femur FractureAdrenocortical Steroid TherapyArteriosclerosis Coronary ArteryArthritisArthropathy

Showing 15 of 323 indications

Risedronate brand names and reporting trend

Risedronate is sold under the brand name Atelvia.

Brand names

Atelvia18,031

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking risedronate with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.