OpenClaim

Risdiplam Side Effects

The most commonly reported side effects of risdiplam include no adverse event, diarrhoea, and asthenia, based on 3,846 FDA adverse event reports from 2020 to 2025. 3.3% of reports found the drug to be ineffective.

Risdiplam side effects

Percentages show how often each reaction appears relative to total reports for risdiplam.

1
No Adverse Event8.6%331
2
Diarrhoea7.5%288
3
Asthenia5.6%217
4
Pneumonia5.1%198
5
Death4.9%187
6
Pyrexia4.5%173
7
Fatigue3.9%151
8
Muscular Weakness3.6%138
9
Vomiting3.5%134
10
Drug Ineffective3.3%126
11
Headache2.8%108
12
Rash2.8%107
13
Covid-192.7%105
14
Nausea2.5%98
15
Product Dose Omission Issue2.3%90

These are voluntary reports and do not establish that risdiplam caused these reactions.

Report severity

43.2%Serious1,663 reports
20.6%Hospitalizations793 reports
9.6%Fatal371 reports

Seriousness is determined by the reporter, not by OpenClaim.

Risdiplam drug interactions

Other drugs that appear in adverse event reports alongside risdiplam. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Nusinersen-sodium3.3%128
2
Oseltamivir-phosphate0.2%8
3
Albuterol0.2%7
4
Palivizumab0.2%6
5
Citalopram-hydrobromide0.2%6
6
Acetaminophen0.2%6
7
Omeprazole0.1%5
8
Ceftriaxone-sodium0.1%5
9
Amoxicillin0.1%4
10
Azithromycin0.1%4
11
Dornase-alfa0.1%4
12
Clindamycin0.1%4
13
Ethinyl-estradiol0.1%4
14
Diazepam0.1%4
15
Estropipate0.1%4

Taken alongside

1
Albuterol2.5%98
2
Cholecalciferol1.7%67
3
Nusinersen-sodium1.5%59
4
Acetaminophen1.3%49
5
Ergocalciferol1.2%45
6
Omeprazole1.2%45
7
Polyethylene-glycol-33501.0%40
8
Cetirizine-hydrochloride1.0%40
9
Ibuprofen1.0%38
10
Gabapentin0.9%34
11
Fluticasone0.9%33
12
Famotidine0.8%31
13
Budesonide0.8%29
14
Sodium-chloride0.7%26
15
Ondansetron0.6%23

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports risdiplam side effects

47.2% of risdiplam adverse event reports involve female patients and 37.6% involve male patients. The largest age group is adult at 47%. These figures reflect who reports side effects, not underlying risk.

Sex

Female47.2%
Male37.6%
Unknown15.1%

Age group

< 212.3%
2–1126.8%
12–1711.2%
18–6446.9%
65+2.8%

What is risdiplam used for

Conditions and purposes for which patients were taking risdiplam when the adverse event was reported.

AmniocentesisBreath HoldingDisabilityDuchenne Muscular DystrophyGene MutationLumbar Spinal StenosisMuscle AtrophyMuscle AtrophyMuscular DystrophyMuscular WeaknessNeuralgic AmyotrophyNeuromyopathyProduct Use In Unapproved IndicationProduct Used For Unknown IndicationProduct Used For Unknown Indication

Showing 15 of 23 indications

Risdiplam brand names and reporting trend

Risdiplam is sold under the brand name Evrysdi.

Brand names

Evrysdi637

Quarterly reports (20202025)

2020202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking risdiplam with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.