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Risankizumab Side Effects

The most commonly reported side effects of risankizumab include psoriasis, pain, and fatigue, based on 75,061 FDA adverse event reports from 2007 to 2025. 4.6% of reports found the drug to be ineffective.

Risankizumab side effects

Percentages show how often each reaction appears relative to total reports for risankizumab.

1
Psoriasis9.9%7,463
2
Drug Ineffective4.6%3,465
3
Pain3.8%2,886
4
Fatigue3.8%2,827
5
Arthralgia3.8%2,817
6
Pruritus3.4%2,576
7
Covid-193.0%2,257
8
Surgery2.5%1,907
9
Death2.5%1,867
10
Fall2.5%1,863
11
Headache2.4%1,790
12
Diarrhoea2.4%1,777
13
Crohn^s Disease2.3%1,736
14
Device Issue2.1%1,608
15
Rash1.9%1,396

These are voluntary reports and do not establish that risankizumab caused these reactions.

Report severity

63.3%Serious47,549 reports
21.6%Hospitalizations16,246 reports
3.4%Fatal2,516 reports

Seriousness is determined by the reporter, not by OpenClaim.

Risankizumab drug interactions

Other drugs that appear in adverse event reports alongside risankizumab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Adalimumab1.6%1,210
2
Apremilast0.6%424
3
Secukinumab0.4%297
4
Methotrexate0.4%292
5
Dupilumab0.4%292
6
Ustekinumab0.4%276
7
Upadacitinib0.3%250
8
Infliximab0.3%243
9
Ixekizumab0.2%167
10
Certolizumab-pegol0.2%149
11
Vedolizumab0.2%147
12
Guselkumab0.2%136
13
Prednisone0.2%123
14
Etanercept0.2%118
15
Bimekizumab-bkzx0.1%100

Taken alongside

1
Ergocalciferol1.7%1,310
2
Atorvastatin-calcium1.7%1,268
3
Levothyroxine-sodium1.3%1,010
4
Aspirin1.3%1,007
5
Omeprazole1.3%949
6
Metformin1.2%931
7
Amlodipine1.2%868
8
Acetaminophen1.1%823
9
Metoprolol1.0%739
10
Losartan-potassium1.0%734
11
Pantoprazole-sodium1.0%730
12
Lisinopril1.0%722
13
Prednisone0.9%690
14
Gabapentin0.9%656
15
Rosuvastatin0.8%609

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports risankizumab side effects

53.3% of risankizumab adverse event reports involve female patients and 40.7% involve male patients. The largest age group is adult at 63%. These figures reflect who reports side effects, not underlying risk.

Sex

Female53.3%
Male40.7%
Unknown6.0%

Age group

< 2<0.1%
2–11<0.1%
12–170.2%
18–6463.2%
65+36.5%

What is risankizumab used for

Conditions and purposes for which patients were taking risankizumab when the adverse event was reported.

AlopeciaAnkylosing SpondylitisArthralgiaArthritisAbdominal PainAbscessAcneAcne ConglobataAdult Polyglucosan Body DiseaseAdverse Drug ReactionAlcoholismAlopeciaAnal FistulaAnkylosing SpondylitisAnxiety Disorder

Showing 15 of 293 indications

Risankizumab brand names and reporting trend

Risankizumab is sold under the brand name Skyrizi.

Brand names

Skyrizi4,045

Quarterly reports (20072025)

200720202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking risankizumab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.