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Ripretinib Side Effects

The most commonly reported side effects of ripretinib include fatigue, alopecia, and death, based on 4,632 FDA adverse event reports from 2020 to 2025. 6.8% of reports found the drug to be ineffective.

Ripretinib side effects

Percentages show how often each reaction appears relative to total reports for ripretinib.

1
Fatigue13.2%612
2
Alopecia11.6%536
3
Death7.8%363
4
Extra Dose Administered7.7%357
5
Underdose7.6%351
6
Drug Ineffective6.8%313
7
Nausea6.7%310
8
Hospitalisation6.5%302
9
Disease Progression6.3%292
10
Neoplasm Progression5.7%266
11
Constipation5.7%265
12
Pain5.5%257
13
Diarrhoea5.5%257
14
Muscle Spasms5.0%232
15
Inappropriate Schedule Of Product Administration4.9%226

These are voluntary reports and do not establish that ripretinib caused these reactions.

Report severity

43.8%Serious2,027 reports
20.8%Hospitalizations964 reports
10.2%Fatal472 reports

Seriousness is determined by the reporter, not by OpenClaim.

Ripretinib drug interactions

Other drugs that appear in adverse event reports alongside ripretinib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Avapritinib0.9%44
2
Regorafenib0.6%29
3
Imatinib-mesylate0.6%29
4
Sunitinib-malate0.6%29
5
Cabozantinib0.3%12
6
Nilotinib0.2%8
7
Pazopanib-hydrochloride0.2%8
8
Binimetinib0.2%7
9
Oxycodone0.1%5
10
Apixaban0.1%5
11
Lisinopril0.1%5
12
Pembrolizumab<0.1%4
13
Letrozole<0.1%4
14
Prednisone<0.1%3
15
Apomorphine-hydrochloride<0.1%3

Taken alongside

1
Amlodipine2.5%118
2
Acetaminophen2.0%94
3
Omeprazole1.9%86
4
Levothyroxine-sodium1.8%85
5
Ondansetron1.8%83
6
Ergocalciferol1.5%70
7
Lisinopril1.3%60
8
Aspirin1.3%59
9
Pantoprazole-sodium1.3%59
10
Oxycodone1.2%57
11
Metoprolol1.2%54
12
Cyanocobalamin1.1%51
13
Atorvastatin-calcium1.1%51
14
Prochlorperazine0.9%40
15
Gabapentin0.9%40

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports ripretinib side effects

43.3% of ripretinib adverse event reports involve female patients and 54.6% involve male patients. The largest age group is elderly at 52%. These figures reflect who reports side effects, not underlying risk.

Sex

Female43.3%
Male54.6%
Unknown2.1%

Age group

< 20.0%
2–110.0%
12–17<0.1%
18–6447.8%
65+52.2%

What is ripretinib used for

Conditions and purposes for which patients were taking ripretinib when the adverse event was reported.

Abdominal NeoplasmAnal CancerBenign Connective Tissue NeoplasmBenign NeoplasmBrain Neoplasm MalignantBreast CancerCarcinoid Tumour Of The StomachConnective Tissue NeoplasmCholangiocarcinomaColon CancerConnective Tissue NeoplasmDermatofibrosarcoma ProtuberansDesmoid TumourEmbolism VenousGastric Cancer

Showing 15 of 80 indications

Ripretinib brand names and reporting trend

Ripretinib is sold under the brand name Qinlock.

Brand names

Qinlock155

Quarterly reports (20202025)

2020202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking ripretinib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.