OpenClaim

Rimegepant Side Effects

The most commonly reported side effects of rimegepant include nausea, migraine, and headache, based on 12,381 FDA adverse event reports from 2020 to 2025. 32.4% of reports found the drug to be ineffective.

Rimegepant side effects

Percentages show how often each reaction appears relative to total reports for rimegepant.

1
Drug Ineffective32.4%4,012
2
Nausea9.4%1,163
3
Migraine6.8%843
4
Headache6.2%768
5
Therapeutic Product Effect Incomplete5.2%648
6
Off Label Use4.0%499
7
Dizziness3.7%454
8
Fatigue3.5%437
9
Vomiting3.0%368
10
Feeling Abnormal2.6%317
11
Somnolence2.3%287
12
Pain2.2%272
13
Rash2.2%270
14
Product Dose Omission Issue2.2%268
15
Pruritus2.0%245

These are voluntary reports and do not establish that rimegepant caused these reactions.

Report severity

19.6%Serious2,424 reports
5.7%Hospitalizations701 reports
0.8%Fatal99 reports

Seriousness is determined by the reporter, not by OpenClaim.

Rimegepant drug interactions

Other drugs that appear in adverse event reports alongside rimegepant. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Galcanezumab-gnlm3.4%416
2
Acetaminophen2.5%305
3
Eptinezumab-jjmr2.3%286
4
Erenumab-aooe2.2%273
5
Onabotulinumtoxina2.2%268
6
Sodium-oxybate2.2%268
7
Dupilumab2.0%244
8
Fremanezumab-vfrm1.2%153
9
Ubrogepant1.2%152
10
Sumatriptan1.2%149
11
Calcium-oxybate1.2%144
12
Magnesium-oxybate1.2%144
13
Potassium-oxybate1.2%144
14
Atogepant1.0%119
15
Ibuprofen0.9%109

Taken alongside

1
Acetaminophen6.8%837
2
Ergocalciferol6.0%748
3
Ondansetron5.3%653
4
Gabapentin5.0%620
5
Albuterol4.6%569
6
Levothyroxine-sodium4.5%557
7
Topiramate4.3%532
8
Fluticasone4.1%510
9
Sumatriptan3.8%465
10
Omeprazole3.7%457
11
Aspirin3.7%452
12
Montelukast-sodium3.4%424
13
Onabotulinumtoxina3.4%419
14
Cetirizine-hydrochloride3.1%384
15
Ibuprofen3.0%366

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports rimegepant side effects

65.6% of rimegepant adverse event reports involve female patients and 10.4% involve male patients. The largest age group is adult at 82%. These figures reflect who reports side effects, not underlying risk.

Sex

Female65.6%
Male10.4%
Unknown24.1%

Age group

< 20.9%
2–110.1%
12–170.8%
18–6481.7%
65+16.4%

What is rimegepant used for

Conditions and purposes for which patients were taking rimegepant when the adverse event was reported.

AuraAbdominal MigraineAbortionAdverse Drug ReactionAmnesiaAnxietyAtypical MigraineAuraBasilar MigraineBreakthrough PainBack PainBasilar MigraineBrain InjuryBrain NeoplasmBreakthrough Pain

Showing 15 of 97 indications

Rimegepant brand names and reporting trend

Rimegepant is sold under brand names including Rimegepant, Nurtec Odt.

Brand names

Rimegepant440
Nurtec Odt42

Quarterly reports (20202025)

2020202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking rimegepant with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.