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Rilzabrutinib Side Effects

The most commonly reported side effects of rilzabrutinib include diarrhoea, nausea, and platelet count decreased, based on 88 FDA adverse event reports from 2024 to 2025. 6.8% of reports found the drug to be ineffective.

Rilzabrutinib side effects

Percentages show how often each reaction appears relative to total reports for rilzabrutinib.

1
Diarrhoea34.1%30
2
Nausea22.7%20
3
Platelet Count Decreased19.3%17
4
Fatigue9.1%8
5
Vomiting9.1%8
6
Headache8.0%7
7
Drug Ineffective6.8%6
8
Platelet Count Abnormal6.8%6
9
Dizziness5.7%5
10
Abdominal Discomfort4.5%4
11
Asthenia4.5%4
12
Insomnia4.5%4
13
Urinary Tract Infection3.4%3
14
Rash3.4%3
15
Cough3.4%3

These are voluntary reports and do not establish that rilzabrutinib caused these reactions.

Report severity

12.5%Serious11 reports
8.0%Hospitalizations7 reports
0.0%Fatal0 reports

Seriousness is determined by the reporter, not by OpenClaim.

Rilzabrutinib drug interactions

Other drugs that appear in adverse event reports alongside rilzabrutinib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Romiplostim2.3%2
2
Rituximab1.1%1
3
Dexamethasone1.1%1

Taken alongside

1
Prednisone20.5%18
2
Atorvastatin-calcium15.9%14
3
Acetaminophen15.9%14
4
Ergocalciferol12.5%11
5
Amlodipine11.4%10
6
Albuterol10.2%9
7
Metoprolol10.2%9
8
Lisinopril9.1%8
9
Romiplostim9.1%8
10
Dexamethasone9.1%8
11
Rosuvastatin6.8%6
12
Ondansetron6.8%6
13
Tamsulosin-hydrochloride6.8%6
14
Levothyroxine-sodium6.8%6
15
Buspirone-hydrochloride5.7%5

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports rilzabrutinib side effects

58.0% of rilzabrutinib adverse event reports involve female patients and 34.1% involve male patients. The largest age group is adult at 53%. These figures reflect who reports side effects, not underlying risk.

Sex

Female58.0%
Male34.1%
Unknown8.0%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6453.2%
65+46.8%

What is rilzabrutinib used for

Conditions and purposes for which patients were taking rilzabrutinib when the adverse event was reported.

Chronic Myelomonocytic LeukaemiaGastrointestinal HaemorrhageGlucose-6-phosphate Dehydrogenase DeficiencyImmune ThrombocytopeniaThrombocytopenia

Rilzabrutinib brand names and reporting trend

Rilzabrutinib is sold under the brand name Wayrilz.

Brand names

Wayrilz10

Quarterly reports (20242025)

20242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking rilzabrutinib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.