OpenClaim

Rilpivirine Side Effects

The most commonly reported side effects of rilpivirine include bone density decreased, renal injury, and skeletal injury, based on 23,811 FDA adverse event reports from 2008 to 2025.

Rilpivirine side effects

Percentages show how often each reaction appears relative to total reports for rilpivirine.

1
Bone Density Decreased18.4%4,387
2
Renal Injury13.5%3,213
3
Skeletal Injury12.5%2,977
4
Chronic Kidney Disease11.2%2,676
5
Pain11.1%2,632
6
Tooth Loss10.0%2,387
7
Renal Failure9.0%2,144
8
Anxiety8.7%2,063
9
Emotional Distress8.5%2,028
10
Tooth Injury8.3%1,975
11
Bone Loss8.1%1,929
12
Osteonecrosis7.9%1,883
13
Multiple Fractures7.9%1,872
14
Osteoporosis7.8%1,865
15
Anhedonia7.6%1,800

These are voluntary reports and do not establish that rilpivirine caused these reactions.

Report severity

53.7%Serious12,791 reports
8.5%Hospitalizations2,014 reports
2.4%Fatal565 reports

Seriousness is determined by the reporter, not by OpenClaim.

Rilpivirine drug interactions

Other drugs that appear in adverse event reports alongside rilpivirine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Cabotegravir46.1%10,977
2
Tenofovir40.5%9,636
3
Emtricitabine40.0%9,533
4
Efavirenz21.8%5,184
5
Cobicistat14.4%3,427
6
Elvitegravir14.1%3,346
7
Dolutegravir7.8%1,869
8
Lamivudine3.4%816
9
Abacavir2.6%625
10
Darunavir1.8%417
11
Ritonavir1.7%412
12
Zidovudine1.0%238
13
Raltegravir-potassium0.9%218
14
Nevirapine0.7%178
15
Bictegravir0.7%171

Taken alongside

1
Emtricitabine25.6%6,084
2
Tenofovir25.5%6,060
3
Bictegravir10.0%2,378
4
Cobicistat7.3%1,731
5
Elvitegravir5.7%1,349
6
Dolutegravir5.3%1,265
7
Lamivudine3.4%798
8
Darunavir3.0%721
9
Ritonavir2.4%573
10
Abacavir2.3%550
11
Cabotegravir2.2%531
12
Ergocalciferol2.0%476
13
Atorvastatin-calcium2.0%467
14
Aspirin1.9%464
15
Acetaminophen1.9%441

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports rilpivirine side effects

23.2% of rilpivirine adverse event reports involve female patients and 55.9% involve male patients. The largest age group is adult at 91%. These figures reflect who reports side effects, not underlying risk.

Sex

Female23.2%
Male55.9%
Unknown20.9%

Age group

< 20.7%
2–11<0.1%
12–170.3%
18–6490.9%
65+8.1%

What is rilpivirine used for

Conditions and purposes for which patients were taking rilpivirine when the adverse event was reported.

Acquired Immunodeficiency SyndromeAcute Hiv InfectionAdverse ReactionAidsAntiretroviral TherapyAntiviral TreatmentAnxiety DisorderAsymptomatic Hiv InfectionAcquired Immunodeficiency SyndromeAcute Hiv InfectionAdverse Drug ReactionAlcoholismAntiretroviral TherapyAntiviral ProphylaxisAntiviral Treatment

Showing 15 of 121 indications

Rilpivirine brand names and reporting trend

Rilpivirine is sold under brand names including Cabenuva Kit, Edurant Ped.

Brand names

Cabenuva Kit7,823
Edurant Ped6

Quarterly reports (20082025)

2008201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking rilpivirine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.