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Rifapentine Side Effects

The most commonly reported side effects of rifapentine include pyrexia, drug interaction, and nausea, based on 492 FDA adverse event reports from 2007 to 2025.

Rifapentine side effects

Percentages show how often each reaction appears relative to total reports for rifapentine.

1
Pyrexia13.0%64
2
Drug Interaction12.6%62
3
Nausea10.0%49
4
Hypertension8.1%40
5
Fatigue7.5%37
6
Off Label Use7.3%36
7
Vomiting6.9%34
8
Dizziness6.9%34
9
Headache6.7%33
10
Rash6.3%31
11
Dyspnoea5.9%29
12
Influenza Like Illness5.5%27
13
Chills4.7%23
14
Hypotension4.7%23
15
Myalgia4.1%20

These are voluntary reports and do not establish that rifapentine caused these reactions.

Report severity

70.5%Serious347 reports
32.3%Hospitalizations159 reports
2.4%Fatal12 reports

Seriousness is determined by the reporter, not by OpenClaim.

Rifapentine drug interactions

Other drugs that appear in adverse event reports alongside rifapentine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Isoniazid57.7%284
2
Pyrazinamide13.8%68
3
Moxifloxacin-hydrochloride9.1%45
4
Ethambutol-hydrochloride8.5%42
5
Amlodipine5.1%25
6
Levofloxacin4.7%23
7
Linezolid4.3%21
8
Pyridoxine4.3%21
9
Rifampin3.0%15
10
Carvedilol2.2%11
11
Dolutegravir2.0%10
12
Losartan-potassium1.4%7
13
Mycophenolate1.2%6
14
Infliximab1.2%6
15
Lenalidomide1.2%6

Taken alongside

1
Isoniazid20.3%100
2
Pyridoxine12.2%60
3
Ethambutol-hydrochloride6.1%30
4
Acetaminophen3.9%19
5
Prednisone3.3%16
6
Rifampin3.3%16
7
Furosemide3.0%15
8
Metformin2.8%14
9
Ergocalciferol2.8%14
10
Pyrazinamide2.6%13
11
Gabapentin2.4%12
12
Moxifloxacin-hydrochloride2.4%12
13
Hydroxychloroquine-sulfate2.0%10
14
Ondansetron1.8%9
15
Hydrochlorothiazide1.4%7

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports rifapentine side effects

38.2% of rifapentine adverse event reports involve female patients and 31.9% involve male patients. The largest age group is adult at 80%. These figures reflect who reports side effects, not underlying risk.

Sex

Female38.2%
Male31.9%
Unknown29.9%

Age group

< 20.6%
2–111.1%
12–171.9%
18–6480.0%
65+16.4%

What is rifapentine used for

Conditions and purposes for which patients were taking rifapentine when the adverse event was reported.

Antibiotic ProphylaxisAntibiotic ProphylaxisBrucellosisBone TuberculosisChest X-ray AbnormalCutaneous TuberculosisDisseminated TuberculosisDrug InteractionDrug LevelDrug TherapyDisseminated TuberculosisExposure To Communicable DiseaseEncephalitisGamma Interferon TherapyGranuloma

Showing 15 of 42 indications

Rifapentine brand names and reporting trend

Rifapentine is sold under the brand name Priftin.

Brand names

Priftin410

Quarterly reports (20072025)

2007201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking rifapentine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.