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Rifamycin Side Effects

The most commonly reported side effects of rifamycin include treatment failure, drug resistance, and toxic epidermal necrolysis, based on 177 FDA adverse event reports from 2004 to 2025. 8.5% of reports found the drug to be ineffective.

Rifamycin side effects

Percentages show how often each reaction appears relative to total reports for rifamycin.

1
Treatment Failure9.6%17
2
Drug Resistance9.0%16
3
Drug Ineffective8.5%15
4
Toxic Epidermal Necrolysis7.9%14
5
Rash Macular7.3%13
6
Rash7.3%13
7
Rash Erythematous7.3%13
8
Pyrexia6.8%12
9
Blister6.8%12
10
Mouth Ulceration6.2%11
11
Septic Shock6.2%11
12
Skin Infection6.2%11
13
Skin Lesion6.2%11
14
Skin Exfoliation6.2%11
15
Staphylococcal Sepsis6.2%11

These are voluntary reports and do not establish that rifamycin caused these reactions.

Report severity

84.2%Serious149 reports
36.2%Hospitalizations64 reports
24.3%Fatal43 reports

Seriousness is determined by the reporter, not by OpenClaim.

Rifamycin drug interactions

Other drugs that appear in adverse event reports alongside rifamycin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Rifabutin15.8%28
2
Ethambutol-hydrochloride14.7%26
3
Rifampin14.7%26
4
Isoniazid14.1%25
5
Levofloxacin12.4%22
6
Pyrazinamide11.3%20
7
Furosemide10.2%18
8
Omeprazole9.0%16
9
Diazepam9.0%16
10
Pantoprazole-sodium9.0%16
11
Itraconazole9.0%16
12
Azithromycin9.0%16
13
Fludrocortisone-acetate8.5%15
14
Haloperidol8.5%15
15
Amikacin-sulfate8.5%15

Taken alongside

1
Ethambutol-hydrochloride16.9%30
2
Pantoprazole-sodium11.3%20
3
Gentamicin-sulfate11.3%20
4
Hydrocortisone10.7%19
5
Pyrazinamide9.0%16
6
Ranitidine8.5%15
7
Isoniazid8.5%15
8
Piperacillin7.9%14
9
Povidone-iodine7.9%14
10
Omeprazole6.8%12
11
Levothyroxine-sodium6.2%11
12
Calcium6.2%11
13
Magnesium-hydroxide6.2%11
14
Insulin5.6%10
15
Acetaminophen5.6%10

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports rifamycin side effects

55.9% of rifamycin adverse event reports involve female patients and 36.2% involve male patients. The largest age group is adult at 57%. These figures reflect who reports side effects, not underlying risk.

Sex

Female55.9%
Male36.2%
Unknown7.9%

Age group

< 24.7%
2–111.4%
12–171.4%
18–6456.8%
65+35.8%

What is rifamycin used for

Conditions and purposes for which patients were taking rifamycin when the adverse event was reported.

Antiretroviral TherapyAtypical Mycobacterial InfectionAmmonia IncreasedAntibiotic ProphylaxisAntibiotic TherapyAtypical Mycobacterial InfectionBacterial InfectionBronchitisBronchiectasisConjunctivitisConjunctivitisConjunctivitis BacterialDrug Use For Unknown IndicationExtradural AbscessFungal Skin Infection

Showing 15 of 45 indications

Rifamycin brand names and reporting trend

Rifamycin is sold under the brand name Aemcolo.

Brand names

Aemcolo182

Quarterly reports (20042025)

200520152025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking rifamycin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.