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Riboflavin Side Effects

The most commonly reported side effects of riboflavin include flushing, off label use, and nausea, based on 7,852 FDA adverse event reports from 2004 to 2025. 8.6% of reports found the drug to be ineffective.

Riboflavin side effects

Percentages show how often each reaction appears relative to total reports for riboflavin.

1
Flushing9.2%723
2
Off Label Use8.7%683
3
Drug Ineffective8.6%677
4
Nausea7.9%620
5
Pain6.4%503
6
Fatigue5.6%442
7
Drug Hypersensitivity5.5%432
8
Dyspnoea5.5%432
9
Headache5.1%397
10
Vomiting4.9%381
11
Drug Intolerance4.5%354
12
Product Use In Unapproved Indication4.4%346
13
Sleep Disorder4.3%341
14
Condition Aggravated4.3%338
15
Swelling4.2%328

These are voluntary reports and do not establish that riboflavin caused these reactions.

Report severity

60.0%Serious4,710 reports
34.5%Hospitalizations2,711 reports
10.8%Fatal845 reports

Seriousness is determined by the reporter, not by OpenClaim.

Riboflavin drug interactions

Other drugs that appear in adverse event reports alongside riboflavin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Niacin11.0%867
2
Ascorbic-acid10.2%798
3
Adalimumab10.0%786
4
Folic-acid8.8%691
5
Acetaminophen8.3%651
6
Thiamine8.1%635
7
Ergocalciferol6.9%542
8
Pyridoxine6.7%529
9
Hydrocortisone6.3%491
10
Etanercept5.9%467
11
Infliximab5.9%461
12
Calcium5.8%455
13
Prednisone5.8%453
14
Erenumab-aooe5.6%437
15
Hydroxychloroquine-sulfate5.5%431

Taken alongside

1
Ergocalciferol66.5%5,223
2
Ascorbic-acid61.7%4,848
3
Thiamine60.1%4,721
4
Cyanocobalamin59.9%4,704
5
Folic-acid59.7%4,687
6
Pyridoxine57.8%4,535
7
Biotin56.6%4,447
8
Vitamin-e54.6%4,289
9
Dexpanthenol54.5%4,277
10
Vitamin-a53.7%4,219
11
Niacinamide53.4%4,191
12
Aspirin23.5%1,848
13
Acetaminophen16.7%1,309
14
Calcium15.3%1,201
15
Fish11.0%865

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports riboflavin side effects

56.8% of riboflavin adverse event reports involve female patients and 35.9% involve male patients. The largest age group is adult at 61%. These figures reflect who reports side effects, not underlying risk.

Sex

Female56.8%
Male35.9%
Unknown7.3%

Age group

< 21.3%
2–111.3%
12–172.4%
18–6461.4%
65+33.5%

What is riboflavin used for

Conditions and purposes for which patients were taking riboflavin when the adverse event was reported.

Acad9 DeficiencyAnaemiaAnaemia ProphylaxisAngina PectorisAnorexiaAstheniaAcneBehcet's SyndromeBlood Lactate Dehydrogenase AbnormalCardiac DisorderCardiomyopathyCervicobrachial SyndromeChemotherapyChronic Fatigue SyndromeChronic Kidney Disease

Showing 15 of 187 indications

Riboflavin brand names and reporting trend

Riboflavin is sold under the brand name M.v.i.-12 Adult.

Brand names

M.v.i.-12 Adult3,668

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking riboflavin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.