OpenClaim

Revefenacin Side Effects

The most commonly reported side effects of revefenacin include dyspnoea, fatigue, and death, based on 693 FDA adverse event reports from 2019 to 2025. 4.3% of reports found the drug to be ineffective.

Revefenacin side effects

Percentages show how often each reaction appears relative to total reports for revefenacin.

1
Dyspnoea23.5%163
2
Fatigue6.9%48
3
Death6.6%46
4
Headache6.6%46
5
Cough6.3%44
6
Pneumonia5.9%41
7
Nausea5.6%39
8
Chronic Obstructive Pulmonary Disease5.5%38
9
Dizziness5.1%35
10
Off Label Use4.8%33
11
Product Dose Omission Issue4.6%32
12
Drug Ineffective4.3%30
13
Diarrhoea4.0%28
14
Asthenia3.9%27
15
Malaise3.6%25

These are voluntary reports and do not establish that revefenacin caused these reactions.

Report severity

52.1%Serious361 reports
22.1%Hospitalizations153 reports
9.8%Fatal68 reports

Seriousness is determined by the reporter, not by OpenClaim.

Revefenacin drug interactions

Other drugs that appear in adverse event reports alongside revefenacin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Dupilumab11.1%77
2
Treprostinil7.8%54
3
Budesonide3.5%24
4
Arformoterol-tartrate3.3%23
5
Formoterol3.0%21
6
Ensifentrine3.0%21
7
Apixaban2.6%18
8
Albuterol2.3%16
9
Fluticasone1.6%11
10
Vilanterol-trifenatate1.4%10
11
Umeclidinium-bromide1.3%9
12
Cenegermin-bkbj1.2%8
13
Tiotropium-bromide1.0%7
14
Glycopyrrolate1.0%7
15
Nintedanib0.9%6

Taken alongside

1
Albuterol42.3%293
2
Budesonide37.2%258
3
Formoterol25.0%173
4
Arformoterol-tartrate18.3%127
5
Ergocalciferol17.2%119
6
Prednisone16.7%116
7
Atorvastatin-calcium16.5%114
8
Montelukast-sodium15.6%108
9
Acetaminophen15.4%107
10
Furosemide14.6%101
11
Aspirin14.6%101
12
Oxygen14.4%100
13
Fluticasone13.7%95
14
Metoprolol13.0%90
15
Levothyroxine-sodium11.5%80

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports revefenacin side effects

56.6% of revefenacin adverse event reports involve female patients and 36.5% involve male patients. The largest age group is elderly at 81%. These figures reflect who reports side effects, not underlying risk.

Sex

Female56.6%
Male36.5%
Unknown6.9%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6419.5%
65+80.5%

What is revefenacin used for

Conditions and purposes for which patients were taking revefenacin when the adverse event was reported.

AsthmaAsthmaAsthma-chronic Obstructive Pulmonary Disease Overlap SyndromeBronchiectasisBronchitis ChronicBronchitis ChronicChronic Obstructive Pulmonary DiseaseCoughChronic Obstructive Pulmonary DiseaseCoughDyspnoeaDyspnoeaEmphysemaEmphysemaLung Disorder

Showing 15 of 30 indications

Revefenacin brand names and reporting trend

Revefenacin is sold under the brand name Yupelri.

Brand names

Yupelri33

Quarterly reports (20192025)

20192020202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking revefenacin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.