OpenClaim

Retifanlimab Side Effects

The most commonly reported side effects of retifanlimab include diarrhoea, nausea, and off label use, based on 132 FDA adverse event reports from 2020 to 2025.

#1 Reported: DiarrhoeaAll side effects ↓Top Co-Medication: CarboplatinDrug interactions ↓59% of Reports Are AdultDemographics ↓

Retifanlimab side effects

Percentages show how often each reaction appears relative to total reports for retifanlimab.

1
Diarrhoea19.7%26
2
Nausea11.4%15
3
Off Label Use11.4%15
4
Disease Progression9.8%13
5
White Blood Cell Count Decreased9.1%12
6
Pulmonary Embolism9.1%12
7
Neutrophil Count Decreased9.1%12
8
Neutropenic Sepsis8.3%11
9
Asthenia7.6%10
10
Malaise6.8%9
11
Pyrexia6.8%9
12
Vomiting6.8%9
13
Condition Aggravated6.8%9
14
Haematocrit Decreased6.1%8
15
Red Blood Cell Count Decreased6.1%8

These are voluntary reports and do not establish that retifanlimab caused these reactions.

Report severity

90.2%Serious119 reports
75.8%Hospitalizations100 reports
18.9%Fatal25 reports

Seriousness is determined by the reporter, not by OpenClaim.

Retifanlimab drug interactions

Other drugs that appear in adverse event reports alongside retifanlimab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Carboplatin57.6%76
2
Paclitaxel45.5%60
3
Pemetrexed9.8%13
4
Margetuximab-cmkb6.8%9
5
Methylprednisolone6.1%8
6
Morphine-sulfate3.8%5
7
Scopolamine3.8%5
8
Enoxaparin-sodium3.8%5
9
Prednisone3.8%5
10
Docetaxel2.3%3
11
Cyanocobalamin1.5%2
12
Gemcitabine1.5%2
13
Nivolumab1.5%2
14
Pembrolizumab1.5%2
15
Diazepam0.8%1

Taken alongside

1
Acetaminophen7.6%10
2
Omeprazole6.8%9
3
Methylprednisolone5.3%7
4
Metoclopramide-hydrochloride5.3%7
5
Gabapentin4.5%6
6
Ondansetron4.5%6
7
Diphenhydramine4.5%6
8
Prednisone4.5%6
9
Apixaban4.5%6
10
Morphine-sulfate4.5%6
11
Filgrastim4.5%6
12
Oxycodone3.8%5
13
Dexamethasone3.8%5
14
Carboplatin3.8%5
15
Cycloserine3.8%5

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports retifanlimab side effects

44.7% of retifanlimab adverse event reports involve female patients and 22.0% involve male patients. The largest age group is adult at 59%. These figures reflect who reports side effects, not underlying risk.

Sex

Female44.7%
Male22.0%
Unknown33.3%

Age group

< 21.2%
2–110.0%
12–170.0%
18–6459.3%
65+39.5%

What is retifanlimab used for

Conditions and purposes for which patients were taking retifanlimab when the adverse event was reported.

Anal Squamous Cell CarcinomaAnal CancerAnal Cancer MetastaticAnal Cancer Stage 0Anal Squamous Cell CarcinomaAngiosarcomaAngiosarcoma MetastaticCholangiocarcinomaColon CancerEndometrial CancerGastric CancerGastric CancerGastrooesophageal CancerGlioblastoma MultiformeHead And Neck Cancer

Showing 15 of 29 indications

Retifanlimab brand names and reporting trend

Retifanlimab is sold under the brand name Zynyz.

Brand names

Zynyz137

Quarterly reports (2020–2025)

2020202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking retifanlimab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.

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