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Resmetirom Side Effects

The most commonly reported side effects of resmetirom include diarrhoea, nausea, and pruritus, based on 1,209 FDA adverse event reports from 2014 to 2025.

Resmetirom side effects

Percentages show how often each reaction appears relative to total reports for resmetirom.

1
Diarrhoea18.7%226
2
Nausea16.4%198
3
Pruritus15.3%185
4
Alanine Aminotransferase Increased8.9%107
5
Aspartate Aminotransferase Increased8.6%104
6
Fatigue7.4%89
7
Abdominal Pain Upper7.1%86
8
Dizziness6.7%81
9
Weight Decreased6.0%73
10
Vomiting6.0%72
11
Hepatic Enzyme Increased4.6%56
12
Rash4.5%54
13
Abdominal Pain4.4%53
14
Hepatic Cirrhosis4.1%50
15
Constipation4.1%49

These are voluntary reports and do not establish that resmetirom caused these reactions.

Report severity

27.9%Serious337 reports
6.1%Hospitalizations74 reports
3.6%Fatal43 reports

Seriousness is determined by the reporter, not by OpenClaim.

Resmetirom drug interactions

Other drugs that appear in adverse event reports alongside resmetirom. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Dupilumab2.8%34
2
Semaglutide0.7%9
3
Tirzepatide0.7%8
4
Abatacept0.6%7
5
Rosuvastatin0.5%6
6
Warfarin0.4%5
7
Dulaglutide0.3%4
8
Acetaminophen0.2%3
9
Risankizumab-rzaa0.2%3
10
Calcium-oxybate0.2%2
11
Magnesium-oxybate0.2%2
12
Potassium-oxybate0.2%2
13
Sodium-oxybate0.2%2
14
Apremilast0.2%2
15
Etanercept0.2%2

Taken alongside

1
Metformin10.8%131
2
Atorvastatin-calcium9.5%115
3
Ergocalciferol8.9%107
4
Levothyroxine-sodium8.0%97
5
Pantoprazole-sodium6.6%80
6
Aspirin6.1%74
7
Omeprazole6.0%72
8
Rosuvastatin5.8%70
9
Metoprolol5.5%67
10
Losartan-potassium5.5%66
11
Lisinopril4.9%59
12
Tirzepatide4.5%54
13
Semaglutide4.5%54
14
Amlodipine4.4%53
15
Hydrochlorothiazide4.1%50

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports resmetirom side effects

6.9% of resmetirom adverse event reports involve female patients and 3.8% involve male patients. The largest age group is adult at 70%. These figures reflect who reports side effects, not underlying risk.

Sex

Female6.9%
Male3.8%
Unknown89.2%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6470.1%
65+29.9%

What is resmetirom used for

Conditions and purposes for which patients were taking resmetirom when the adverse event was reported.

Alcoholic Liver DiseaseBiliary Tract DisorderBlood Test AbnormalEnzyme AbnormalityEnzyme Level AbnormalFibrosisGastrointestinal InflammationHepatic CirrhosisHepatic FibrosisHepatic SteatosisHepatitisHepatitis CIllnessLiver DisorderLiver Function Test Abnormal

Showing 15 of 25 indications

Resmetirom brand names and reporting trend

Resmetirom is sold under the brand name Rezdiffra.

Brand names

Rezdiffra7

Quarterly reports (20142025)

20142025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking resmetirom with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.