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Repotrectinib Side Effects

The most commonly reported side effects of repotrectinib include dizziness, death, and nausea, based on 215 FDA adverse event reports from 2022 to 2025.

Repotrectinib side effects

Percentages show how often each reaction appears relative to total reports for repotrectinib.

1
Dizziness15.8%34
2
Death10.2%22
3
Nausea8.4%18
4
Neuropathy Peripheral7.4%16
5
Fatigue6.0%13
6
Adverse Event5.6%12
7
Off Label Use5.6%12
8
Muscular Weakness4.7%10
9
Paraesthesia4.7%10
10
Balance Disorder4.2%9
11
Pain4.2%9
12
Gait Disturbance4.2%9
13
Hospitalisation3.7%8
14
Pulmonary Embolism3.7%8
15
Treatment Noncompliance3.3%7

These are voluntary reports and do not establish that repotrectinib caused these reactions.

Report severity

64.7%Serious139 reports
26.5%Hospitalizations57 reports
13.0%Fatal28 reports

Seriousness is determined by the reporter, not by OpenClaim.

Repotrectinib drug interactions

Other drugs that appear in adverse event reports alongside repotrectinib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Entrectinib3.3%7
2
Carboplatin3.3%7
3
Larotrectinib-sulfate2.8%6
4
Levoleucovorin2.8%6
5
Ipilimumab2.3%5
6
Oxaliplatin2.3%5
7
Fluorouracil2.3%5
8
Etoposide2.3%5
9
Nivolumab2.3%5
10
Gemcitabine1.9%4
11
Pemetrexed1.4%3
12
Crizotinib1.4%3
13
Lorlatinib0.9%2
14
Bevacizumab0.9%2
15
Lipase0.9%2

Taken alongside

1
Amlodipine2.3%5
2
Larotrectinib-sulfate1.9%4
3
Lorlatinib1.4%3
4
Ergocalciferol1.4%3
5
Levothyroxine-sodium1.4%3
6
Acetaminophen1.4%3
7
Prochlorperazine1.4%3
8
Ondansetron1.4%3
9
Capecitabine1.4%3
10
Temozolomide1.4%3
11
Levetiracetam1.4%3
12
Pembrolizumab0.9%2
13
Metoprolol0.9%2
14
Rivaroxaban0.9%2
15
Aspirin0.9%2

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports repotrectinib side effects

53.5% of repotrectinib adverse event reports involve female patients and 32.6% involve male patients. The largest age group is adult at 53%. These figures reflect who reports side effects, not underlying risk.

Sex

Female53.5%
Male32.6%
Unknown14.0%

Age group

< 20.6%
2–111.9%
12–170.0%
18–6453.1%
65+44.4%

What is repotrectinib used for

Conditions and purposes for which patients were taking repotrectinib when the adverse event was reported.

Adenosquamous Cell Lung CancerAstrocytoma, Low GradeBronchial CarcinomaBronchitisCongenital FibrosarcomaGastric CancerLung AdenocarcinomaLung Adenocarcinoma Stage IvLung Cancer MetastaticLung Carcinoma Cell Type Unspecified Stage 0Lung Carcinoma Cell Type Unspecified Stage IvLung DisorderLung NeoplasmLung Neoplasm MalignantMetastases To Central Nervous System

Showing 15 of 24 indications

Repotrectinib brand names and reporting trend

Repotrectinib is sold under the brand name Augtyro.

Brand names

Augtyro66

Quarterly reports (20222025)

202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking repotrectinib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.