OpenClaim

Repository Side Effects

The most commonly reported side effects of repository include fatigue, weight increased, and malaise, based on 6,298 FDA adverse event reports from 2006 to 2025. 7.8% of reports found the drug to be ineffective.

Repository side effects

Percentages show how often each reaction appears relative to total reports for repository.

1
Fatigue9.5%601
2
Weight Increased8.2%518
3
Drug Ineffective7.8%489
4
Malaise7.2%453
5
Dyspnoea6.9%435
6
Insomnia6.3%399
7
Injection Site Bruising6.3%398
8
Headache5.9%371
9
Pain5.8%364
10
Asthenia5.4%339
11
Peripheral Swelling5.3%335
12
Blood Pressure Increased5.0%314
13
Fluid Retention4.8%305
14
Blood Glucose Increased4.8%301
15
Nausea4.6%287

These are voluntary reports and do not establish that repository caused these reactions.

Report severity

57.7%Serious3,632 reports
26.5%Hospitalizations1,666 reports
6.0%Fatal377 reports

Seriousness is determined by the reporter, not by OpenClaim.

Repository drug interactions

Other drugs that appear in adverse event reports alongside repository. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Prednisone2.3%147
2
Dalfampridine0.7%43
3
Methotrexate0.6%38
4
Furosemide0.4%24
5
Teriflunomide0.3%22
6
Rituximab0.3%21
7
Vigabatrin0.3%20
8
Fingolimod0.3%19
9
Mycophenolate0.3%19
10
Dimethyl0.3%17
11
Oxycodone0.3%16
12
Metformin0.2%14
13
Apomorphine-hydrochloride0.2%13
14
Methylprednisolone0.2%12
15
Acetaminophen0.2%12

Taken alongside

1
Prednisone9.2%577
2
Ergocalciferol5.8%363
3
Furosemide5.1%321
4
Gabapentin4.5%281
5
Levothyroxine-sodium3.8%242
6
Acetaminophen3.7%232
7
Omeprazole3.6%225
8
Aspirin3.5%219
9
Lisinopril3.4%213
10
Methotrexate3.1%197
11
Atorvastatin-calcium3.1%193
12
Amlodipine3.0%189
13
Metoprolol2.9%182
14
Insulin2.6%163
15
Folic-acid2.6%162

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports repository side effects

63.7% of repository adverse event reports involve female patients and 32.8% involve male patients. The largest age group is adult at 67%. These figures reflect who reports side effects, not underlying risk.

Sex

Female63.7%
Male32.8%
Unknown3.5%

Age group

< 24.3%
2–110.6%
12–170.5%
18–6466.6%
65+28.0%

What is repository used for

Conditions and purposes for which patients were taking repository when the adverse event was reported.

Acute Kidney InjuryAddison^s DiseaseAdrenal InsufficiencyAdrenocorticotropic Hormone DeficiencyAlbuminuriaAmyloidosisAmyotrophic Lateral SclerosisAnaemiaAnalgesic TherapyAnkylosing SpondylitisAntiphospholipid SyndromeArthralgiaArthritisArthropathyAsthma

Showing 15 of 324 indications

Repository brand names and reporting trend

Repository is sold under the brand name H.p. Acthar Gel.

Brand names

H.p. Acthar Gel5,092

Quarterly reports (20062025)

2006201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking repository with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.