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Repaglinide Side Effects

The most commonly reported side effects of repaglinide include hypoglycaemia, acute kidney injury, and diarrhoea, based on 10,255 FDA adverse event reports from 2004 to 2025. 2.5% of reports found the drug to be ineffective.

Repaglinide side effects

Percentages show how often each reaction appears relative to total reports for repaglinide.

1
Hypoglycaemia7.7%793
2
Acute Kidney Injury5.8%591
3
Diarrhoea3.8%394
4
Drug Interaction3.7%382
5
Blood Glucose Increased3.7%381
6
Lactic Acidosis3.4%350
7
Nausea3.1%314
8
Blood Glucose Increased3.0%310
9
Dyspnoea3.0%304
10
Nausea2.9%296
11
Asthenia2.6%265
12
Off Label Use2.6%264
13
Drug Ineffective2.5%261
14
Fatigue2.4%251
15
Vomiting2.4%245

These are voluntary reports and do not establish that repaglinide caused these reactions.

Report severity

82.5%Serious8,459 reports
51.7%Hospitalizations5,301 reports
9.0%Fatal919 reports

Seriousness is determined by the reporter, not by OpenClaim.

Repaglinide drug interactions

Other drugs that appear in adverse event reports alongside repaglinide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Metformin13.0%1,335
2
Insulin6.5%670
3
Exenatide-synthetic6.2%636
4
Sitagliptin3.9%402
5
Furosemide3.8%387
6
Hydrochlorothiazide2.9%296
7
Atorvastatin-calcium2.5%253
8
Pantoprazole-sodium2.4%248
9
Lenalidomide2.2%225
10
Bisoprolol-fumarate2.1%216
11
Ramipril2.1%214
12
Aspirin2.1%211
13
Omeprazole1.8%187
14
Prednisone1.8%185
15
Pioglitazone-hydrochloride1.7%174

Taken alongside

1
Metformin27.0%2,767
2
Insulin20.6%2,114
3
Aspirin16.4%1,686
4
Furosemide15.9%1,627
5
Atorvastatin-calcium13.1%1,347
6
Amlodipine11.7%1,204
7
Levothyroxine-sodium9.7%999
8
Pantoprazole-sodium8.7%892
9
Acetaminophen8.5%870
10
Omeprazole8.5%870
11
Simvastatin8.0%824
12
Bisoprolol-fumarate7.7%790
13
Sitagliptin7.5%772
14
Allopurinol7.4%756
15
Metoprolol7.3%751

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports repaglinide side effects

44.3% of repaglinide adverse event reports involve female patients and 48.5% involve male patients. The largest age group is elderly at 70%. These figures reflect who reports side effects, not underlying risk.

Sex

Female44.3%
Male48.5%
Unknown7.2%

Age group

< 2<0.1%
2–11<0.1%
12–170.2%
18–6429.8%
65+69.8%

What is repaglinide used for

Conditions and purposes for which patients were taking repaglinide when the adverse event was reported.

Adverse EventAnaemiaAntiplatelet TherapyAscitesAdverse EventAntibiotic ProphylaxisBenign Prostatic HyperplasiaBlood GlucoseBlood Glucose AbnormalBlood Glucose DecreasedBlood Glucose FluctuationBlood Glucose IncreasedBlood Insulin AbnormalBlood Pressure AbnormalBlood Glucose Abnormal

Showing 15 of 105 indications

Repaglinide brand names and reporting trend

Repaglinide is sold under the brand name Prandimet.

Brand names

Prandimet8,159

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking repaglinide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.