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Relatlimab Side Effects

The most commonly reported side effects of relatlimab include death, off label use, and malignant neoplasm progression, based on 394 FDA adverse event reports from 2022 to 2025.

Relatlimab side effects

Percentages show how often each reaction appears relative to total reports for relatlimab.

1
Death15.5%61
2
Off Label Use11.9%47
3
Malignant Neoplasm Progression7.1%28
4
Myocarditis4.6%18
5
Fatigue3.6%14
6
Rash3.3%13
7
Product Storage Error3.3%13
8
Adverse Event3.0%12
9
Myasthenia Gravis3.0%12
10
Diarrhoea2.5%10
11
Colitis2.5%10
12
Infusion Related Reaction2.0%8
13
Weight Decreased2.0%8
14
Headache1.8%7
15
Dyspnoea1.8%7

These are voluntary reports and do not establish that relatlimab caused these reactions.

Report severity

65.7%Serious259 reports
19.0%Hospitalizations75 reports
21.6%Fatal85 reports

Seriousness is determined by the reporter, not by OpenClaim.

Relatlimab drug interactions

Other drugs that appear in adverse event reports alongside relatlimab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Nivolumab97.7%385
2
Ipilimumab2.3%9
3
Tocilizumab1.3%5
4
Methotrexate0.8%3
5
Tebentafusp-tebn0.5%2
6
Bevacizumab0.5%2
7
Atezolizumab0.5%2
8
Trametinib0.5%2
9
Relugolix0.5%2
10
Filgrastim0.3%1
11
Penicillin0.3%1
12
Prednisone0.3%1
13
Dabrafenib-mesylate0.3%1
14
Vemurafenib0.3%1
15
Cobimetinib-fumarate0.3%1

Taken alongside

1
Levothyroxine-sodium4.3%17
2
Acetaminophen3.3%13
3
Atorvastatin-calcium3.0%12
4
Apixaban2.8%11
5
Ondansetron2.8%11
6
Nivolumab2.8%11
7
Aspirin2.5%10
8
Amlodipine2.3%9
9
Metformin2.3%9
10
Hydrochlorothiazide2.0%8
11
Bisoprolol-fumarate2.0%8
12
Ibuprofen2.0%8
13
Lisinopril1.8%7
14
Pantoprazole-sodium1.8%7
15
Ergocalciferol1.5%6

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports relatlimab side effects

29.4% of relatlimab adverse event reports involve female patients and 42.9% involve male patients. The largest age group is elderly at 63%. These figures reflect who reports side effects, not underlying risk.

Sex

Female29.4%
Male42.9%
Unknown27.7%

Age group

< 20.0%
2–110.8%
12–170.4%
18–6435.8%
65+63.0%

What is relatlimab used for

Conditions and purposes for which patients were taking relatlimab when the adverse event was reported.

Acral Lentiginous Melanoma Stage IvAnal CancerAstrocytoma, Low GradeBone CancerBrain Neoplasm MalignantDuctal Adenocarcinoma Of PancreasEndometrial CancerEssential ThrombocythaemiaFibromaGastric CancerGenital Neoplasm Malignant FemaleGlioblastomaHepatic Cancer MetastaticHepatobiliary CancerHepatocellular Carcinoma

Showing 15 of 45 indications

Relatlimab brand names and reporting trend

Quarterly reports (20222025)

202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking relatlimab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.