The most commonly reported side effects of regorafenib include off label use, fatigue, and palmar-plantar erythrodysaesthesia syndrome, based on 11,512 FDA adverse event reports from 2010 to 2025.
Percentages show how often each reaction appears relative to total reports for regorafenib.
These are voluntary reports and do not establish that regorafenib caused these reactions.
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Other drugs that appear in adverse event reports alongside regorafenib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.
Also suspected
Taken alongside
Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.
36.4% of regorafenib adverse event reports involve female patients and 55.0% involve male patients. The largest age group is adult at 54%. These figures reflect who reports side effects, not underlying risk.
Sex
Age group
Conditions and purposes for which patients were taking regorafenib when the adverse event was reported.
Showing 15 of 458 indications
Regorafenib is sold under the brand name Regorafenib.
An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.
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