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Rauwolfia Side Effects

The most commonly reported side effects of rauwolfia include drug-induced liver injury, international normalised ratio increased, and weight decreased, based on 15 FDA adverse event reports from 2005 to 2024.

Rauwolfia side effects

Percentages show how often each reaction appears relative to total reports for rauwolfia.

1
Drug-induced Liver Injury20.0%3
2
International Normalised Ratio Increased13.3%2
3
Weight Decreased13.3%2
4
Activated Partial Thromboplastin Time Prolonged6.7%1
5
Acute Myocardial Infarction6.7%1
6
Anaemia6.7%1
7
Angina Pectoris6.7%1
8
Angina Unstable6.7%1
9
Arteriosclerosis6.7%1
10
Asthma6.7%1
11
Cardiac Failure Congestive6.7%1
12
Cardiovascular Disorder6.7%1
13
Carotid Arterial Embolus6.7%1
14
Chronic Obstructive Pulmonary Disease6.7%1
15
Coronary Artery Stenosis6.7%1

These are voluntary reports and do not establish that rauwolfia caused these reactions.

Report severity

93.3%Serious14 reports
40.0%Hospitalizations6 reports
13.3%Fatal2 reports

Seriousness is determined by the reporter, not by OpenClaim.

Rauwolfia drug interactions

Other drugs that appear in adverse event reports alongside rauwolfia. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Acyclovir20.0%3
2
Rofecoxib6.7%1
3
Aspirin6.7%1
4
Adalimumab6.7%1
5
Loperamide-hydrochloride6.7%1
6
Captopril6.7%1
7
Warfarin6.7%1
8
Valsartan6.7%1
9
Cetirizine-hydrochloride6.7%1
10
Midazolam6.7%1
11
Propofol6.7%1
12
Secukinumab6.7%1
13
Carbidopa6.7%1
14
Levodopa6.7%1
15
Bremelanotide-acetate6.7%1

Taken alongside

1
Acetaminophen20.0%3
2
Hydrocodone13.3%2
3
Zolpidem-tartrate13.3%2
4
Ferrous-sulfate13.3%2
5
Aspirin13.3%2
6
Prednisone13.3%2
7
Venlafaxine13.3%2
8
Spironolactone13.3%2
9
Cyclobenzaprine-hydrochloride6.7%1
10
Atenolol6.7%1
11
Clorazepate-dipotassium6.7%1
12
Beclomethasone6.7%1
13
Nitroglycerin6.7%1
14
Lansoprazole6.7%1
15
Levothyroxine-sodium6.7%1

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports rauwolfia side effects

73.3% of rauwolfia adverse event reports involve female patients and 26.7% involve male patients. The largest age group is elderly at 54%. These figures reflect who reports side effects, not underlying risk.

Sex

Female73.3%
Male26.7%
Unknown0.0%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6446.2%
65+53.8%

What is rauwolfia used for

Conditions and purposes for which patients were taking rauwolfia when the adverse event was reported.

Benign Prostatic HyperplasiaDepressionDrug Use For Unknown IndicationHypertensionProduct Used For Unknown IndicationPain In ExtremityProduct Used For Unknown Indication

Rauwolfia brand names and reporting trend

Rauwolfia is sold under the brand name Hyserpin.

Brand names

Hyserpin5

Quarterly reports (20052024)

200520202024

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking rauwolfia with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.