OpenClaim

Rasburicase Side Effects

The most commonly reported side effects of rasburicase include tumour lysis syndrome, febrile neutropenia, and off label use, based on 2,343 FDA adverse event reports from 2004 to 2025. 5.3% of reports found the drug to be ineffective.

Rasburicase side effects

Percentages show how often each reaction appears relative to total reports for rasburicase.

1
Tumour Lysis Syndrome14.3%334
2
Febrile Neutropenia7.6%177
3
Off Label Use7.6%177
4
Acute Kidney Injury6.0%141
5
Pyrexia5.8%137
6
Drug Ineffective5.3%125
7
Neutropenia5.1%119
8
Cytokine Release Syndrome4.9%114
9
Sepsis4.0%93
10
Respiratory Failure3.8%88
11
Anaemia3.5%82
12
Hypotension3.2%76
13
Pneumonia3.1%72
14
Multiple Organ Dysfunction Syndrome3.0%71
15
Renal Failure2.9%68

These are voluntary reports and do not establish that rasburicase caused these reactions.

Report severity

91.1%Serious2,135 reports
54.4%Hospitalizations1,274 reports
27.1%Fatal635 reports

Seriousness is determined by the reporter, not by OpenClaim.

Rasburicase drug interactions

Other drugs that appear in adverse event reports alongside rasburicase. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Rituximab17.8%417
2
Vincristine-sulfate16.1%377
3
Venetoclax15.9%372
4
Cyclophosphamide14.8%347
5
Dexamethasone13.7%321
6
Cytarabine12.2%287
7
Doxorubicin-hydrochloride11.5%270
8
Methotrexate9.4%220
9
Prednisone8.7%204
10
Azacitidine6.9%162
11
Etoposide6.0%141
12
Pegaspargase5.9%138
13
Methylprednisolone5.8%137
14
Prednisolone5.5%130
15
Allopurinol5.3%125

Taken alongside

1
Acetaminophen29.1%681
2
Allopurinol28.9%678
3
Ondansetron21.5%503
4
Furosemide19.6%460
5
Acyclovir19.5%458
6
Dexamethasone15.2%357
7
Pantoprazole-sodium14.0%328
8
Sulfamethoxazole12.5%293
9
Omeprazole11.9%278
10
Trimethoprim10.4%243
11
Metoclopramide-hydrochloride9.8%229
12
Filgrastim9.2%215
13
Potassium-chloride9.0%211
14
Fluconazole9.0%211
15
Amoxicillin8.6%202

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports rasburicase side effects

30.7% of rasburicase adverse event reports involve female patients and 55.4% involve male patients. The largest age group is elderly at 45%. These figures reflect who reports side effects, not underlying risk.

Sex

Female30.7%
Male55.4%
Unknown13.9%

Age group

< 21.6%
2–117.0%
12–175.8%
18–6440.5%
65+45.1%

What is rasburicase used for

Conditions and purposes for which patients were taking rasburicase when the adverse event was reported.

Acute Kidney InjuryAcute LeukaemiaAcute Lymphoblastic LeukemiaAcute Lymphocytic LeukaemiaAcute Myeloid LeukaemiaAcute Myeloid Leukaemia RecurrentAdult T-cell Lymphoma/leukaemiaAcute Kidney InjuryAcute Lymphocytic LeukaemiaAcute Monocytic LeukaemiaAcute Myeloid LeukaemiaAcute Myelomonocytic LeukaemiaAcute Myocardial InfarctionAcute Respiratory FailureAdenocarcinoma Gastric

Showing 15 of 170 indications

Rasburicase brand names and reporting trend

Rasburicase is sold under the brand name Elitek.

Brand names

Elitek2,309

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking rasburicase with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.