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Ranolazine Side Effects

The most commonly reported side effects of ranolazine include death, dizziness, and chest pain, based on 19,822 FDA adverse event reports from 2004 to 2025. 2.4% of reports found the drug to be ineffective.

Ranolazine side effects

Percentages show how often each reaction appears relative to total reports for ranolazine.

1
Death5.7%1,124
2
Dizziness5.2%1,037
3
Chest Pain4.9%978
4
Dyspnoea4.8%954
5
Myocardial Infarction4.3%854
6
Angina Pectoris3.9%770
7
Nausea3.7%733
8
Fall3.4%672
9
Fatigue3.3%660
10
Stent Placement3.2%626
11
Off Label Use2.9%583
12
Asthenia2.8%560
13
Headache2.7%530
14
Malaise2.6%519
15
Diarrhoea2.6%511

These are voluntary reports and do not establish that ranolazine caused these reactions.

Report severity

77.0%Serious15,258 reports
38.1%Hospitalizations7,555 reports
10.5%Fatal2,080 reports

Seriousness is determined by the reporter, not by OpenClaim.

Ranolazine drug interactions

Other drugs that appear in adverse event reports alongside ranolazine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Aspirin2.7%528
2
Lenalidomide1.9%383
3
Rivaroxaban1.7%338
4
Pantoprazole-sodium1.6%322
5
Omeprazole1.6%317
6
Esomeprazole1.5%290
7
Valsartan1.5%289
8
Gemfibrozil1.3%259
9
Atorvastatin-calcium1.3%257
10
Apixaban1.2%235
11
Clopidogrel-bisulfate1.1%223
12
Evolocumab1.1%221
13
Amlodipine1.1%214
14
Sacubitril1.1%211
15
Furosemide1.0%200

Taken alongside

1
Aspirin24.3%4,823
2
Atorvastatin-calcium17.4%3,452
3
Metoprolol14.4%2,853
4
Isosorbide13.6%2,698
5
Furosemide13.6%2,695
6
Nitroglycerin13.6%2,690
7
Amlodipine9.7%1,918
8
Pantoprazole-sodium9.4%1,870
9
Clopidogrel-bisulfate9.2%1,833
10
Acetaminophen8.5%1,678
11
Levothyroxine-sodium8.4%1,668
12
Insulin8.4%1,661
13
Ergocalciferol8.2%1,625
14
Omeprazole8.0%1,593
15
Carvedilol7.8%1,542

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports ranolazine side effects

40.1% of ranolazine adverse event reports involve female patients and 54.6% involve male patients. The largest age group is elderly at 67%. These figures reflect who reports side effects, not underlying risk.

Sex

Female40.1%
Male54.6%
Unknown5.2%

Age group

< 20.2%
2–110.1%
12–170.2%
18–6432.5%
65+67.1%

What is ranolazine used for

Conditions and purposes for which patients were taking ranolazine when the adverse event was reported.

Accidental Drug Intake By ChildAcquired HaemophiliaAcute Coronary SyndromeAcute Myocardial InfarctionAdverse EventAnal HaemorrhageAngina AttackAngina PectorisAngina UnstableAnginal EquivalentAngiogram AbnormalAngiopathyAngioplastyAnticoagulant TherapyAntimitochondrial Antibody Positive

Showing 15 of 316 indications

Ranolazine brand names and reporting trend

Ranolazine is sold under the brand name Ranexa.

Brand names

Ranexa11,455

Quarterly reports (20042025)

20042010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking ranolazine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.