OpenClaim

Ranibizumab Side Effects

The most commonly reported side effects of ranibizumab include death, visual acuity reduced, and off label use, based on 26,783 FDA adverse event reports from 2004 to 2025. 4.0% of reports found the drug to be ineffective.

Ranibizumab side effects

Percentages show how often each reaction appears relative to total reports for ranibizumab.

1
Death10.6%2,838
2
Visual Acuity Reduced6.7%1,798
3
Off Label Use6.3%1,683
4
Visual Impairment5.3%1,408
5
Visual Acuity Reduced4.1%1,103
6
Drug Ineffective4.0%1,058
7
No Adverse Event3.9%1,037
8
Death3.6%972
9
Blindness3.6%956
10
Vision Blurred3.4%902
11
Eye Pain2.9%777
12
Cerebrovascular Accident2.8%758
13
Eye Haemorrhage2.6%701
14
Endophthalmitis2.4%637
15
Retinal Haemorrhage2.1%572

These are voluntary reports and do not establish that ranibizumab caused these reactions.

Report severity

85.1%Serious22,791 reports
18.8%Hospitalizations5,046 reports
19.2%Fatal5,129 reports

Seriousness is determined by the reporter, not by OpenClaim.

Ranibizumab drug interactions

Other drugs that appear in adverse event reports alongside ranibizumab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Bevacizumab8.4%2,255
2
Aflibercept3.8%1,013
3
Verteporfin1.7%452
4
Faricimab-svoa1.5%395
5
Brolucizumab-dbll1.1%289
6
Metformin0.4%94
7
Dexamethasone0.3%93
8
Amlodipine0.3%90
9
Atorvastatin-calcium0.3%80
10
Triamcinolone0.3%76
11
Naproxen0.2%65
12
Aspirin0.2%60
13
Furosemide0.2%59
14
Valsartan0.2%56
15
Hydrochlorothiazide0.2%53

Taken alongside

1
Aspirin5.4%1,454
2
Insulin3.7%988
3
Amlodipine3.3%889
4
Metformin3.2%847
5
Atorvastatin-calcium2.9%790
6
Furosemide2.8%739
7
Simvastatin2.7%736
8
Levothyroxine-sodium2.7%728
9
Lisinopril2.2%600
10
Omeprazole2.1%558
11
Acetaminophen2.0%541
12
Metoprolol1.8%482
13
Aflibercept1.8%478
14
Hydrochlorothiazide1.7%449
15
Losartan-potassium1.6%429

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports ranibizumab side effects

48.7% of ranibizumab adverse event reports involve female patients and 38.0% involve male patients. The largest age group is elderly at 75%. These figures reflect who reports side effects, not underlying risk.

Sex

Female48.7%
Male38.0%
Unknown13.3%

Age group

< 21.3%
2–110.2%
12–170.2%
18–6423.4%
65+75.0%

What is ranibizumab used for

Conditions and purposes for which patients were taking ranibizumab when the adverse event was reported.

Abdominal HerniaAbdominal Pain UpperAccidental Exposure To ProductAccidental Exposure To Product By ChildAffect LabilityAge-related Macular DegenerationAmblyopiaAnaemia Of Chronic DiseaseAneurysmAngioedemaAngiogram AbnormalAngiopathyAnkylosing SpondylitisAntacid TherapyAnterior Chamber Opacity

Showing 15 of 437 indications

Ranibizumab brand names and reporting trend

Ranibizumab is sold under brand names including Lucentis, Byooviz.

Brand names

Lucentis11,022
Byooviz2

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking ranibizumab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.