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Ramucirumab Side Effects

The most commonly reported side effects of ramucirumab include malignant neoplasm progression, death, and interstitial lung disease, based on 6,057 FDA adverse event reports from 2010 to 2025. 2.7% of reports found the drug to be ineffective.

Ramucirumab side effects

Percentages show how often each reaction appears relative to total reports for ramucirumab.

1
Malignant Neoplasm Progression13.1%795
2
Death9.3%562
3
Interstitial Lung Disease4.8%293
4
Febrile Neutropenia4.4%265
5
Neutropenia4.3%258
6
Decreased Appetite3.7%223
7
Diarrhoea3.6%221
8
Off Label Use3.5%210
9
Fatigue3.3%197
10
Nausea3.2%196
11
Disease Progression3.1%189
12
Hypertension3.1%185
13
Pyrexia3.0%184
14
Neutrophil Count Decreased2.9%177
15
Neuropathy Peripheral2.8%170

These are voluntary reports and do not establish that ramucirumab caused these reactions.

Report severity

93.8%Serious5,681 reports
38.3%Hospitalizations2,322 reports
26.5%Fatal1,606 reports

Seriousness is determined by the reporter, not by OpenClaim.

Ramucirumab drug interactions

Other drugs that appear in adverse event reports alongside ramucirumab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Paclitaxel22.1%1,338
2
Docetaxel13.8%834
3
Nivolumab5.7%343
4
Irinotecan-hydrochloride5.2%314
5
Fluorouracil5.0%303
6
Oxaliplatin5.0%300
7
Bevacizumab3.4%203
8
Carboplatin2.9%175
9
Cisplatin2.7%163
10
Capecitabine2.6%156
11
Pemetrexed2.4%143
12
Erlotinib-hydrochloride2.3%139
13
Pembrolizumab2.1%126
14
Levoleucovorin2.0%123
15
Gemcitabine2.0%122

Taken alongside

1
Paclitaxel17.2%1,044
2
Docetaxel8.4%507
3
Dexamethasone4.9%296
4
Irinotecan-hydrochloride4.8%288
5
Fluorouracil4.3%259
6
Furosemide2.6%156
7
Amlodipine2.5%153
8
Calcium2.3%141
9
Acetaminophen2.1%130
10
Ondansetron2.1%130
11
Oxaliplatin1.8%112
12
Esomeprazole1.8%109
13
Dexchlorpheniramine-maleate1.8%107
14
Oxycodone1.7%105
15
Levoleucovorin1.7%103

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports ramucirumab side effects

28.7% of ramucirumab adverse event reports involve female patients and 57.5% involve male patients. The largest age group is elderly at 57%. These figures reflect who reports side effects, not underlying risk.

Sex

Female28.7%
Male57.5%
Unknown13.8%

Age group

< 2<0.1%
2–110.0%
12–170.9%
18–6441.6%
65+57.5%

What is ramucirumab used for

Conditions and purposes for which patients were taking ramucirumab when the adverse event was reported.

AdenocarcinomaAdenocarcinoma GastricAdenocarcinoma MetastaticAdenocarcinoma Of ColonAdenocarcinoma PancreasAdenosquamous Cell CarcinomaAdenosquamous Cell Lung CancerAdenosquamous Cell Lung Cancer RecurrentAdenosquamous Cell Lung Cancer Stage IvAlpha 1 Foetoprotein IncreasedAppendix CancerAdenocarcinomaAdenocarcinoma GastricAdenocarcinoma Gastric Stage IvAdenocarcinoma Metastatic

Showing 15 of 294 indications

Ramucirumab brand names and reporting trend

Ramucirumab is sold under the brand name Cyramza.

Brand names

Cyramza2,443

Quarterly reports (20102025)

201020122016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking ramucirumab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.