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Radium Side Effects

The most commonly reported side effects of radium include prostatic specific antigen increased, hormone-refractory prostate cancer, and death, based on 5,090 FDA adverse event reports from 2013 to 2025.

Radium side effects

Percentages show how often each reaction appears relative to total reports for radium.

1
Prostatic Specific Antigen Increased9.4%477
2
Hormone-refractory Prostate Cancer8.9%453
3
Death8.6%438
4
Metastases To Bone6.4%328
5
Anaemia6.0%307
6
General Physical Health Deterioration6.0%307
7
Fatigue5.7%290
8
Haemoglobin Decreased5.0%253
9
Nausea4.9%248
10
Pain4.6%234
11
Disease Progression4.3%221
12
Prostate Cancer4.3%220
13
Diarrhoea4.2%215
14
Malaise4.0%206
15
Asthenia3.9%199

These are voluntary reports and do not establish that radium caused these reactions.

Report severity

88.4%Serious4,500 reports
23.5%Hospitalizations1,196 reports
20.1%Fatal1,023 reports

Seriousness is determined by the reporter, not by OpenClaim.

Radium drug interactions

Other drugs that appear in adverse event reports alongside radium. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Enzalutamide6.8%345
2
Abiraterone-acetate2.4%123
3
Denosumab2.1%109
4
Docetaxel1.9%98
5
Leuprolide1.6%80
6
Cabazitaxel1.1%56
7
Prednisone1.0%49
8
Zoledronic-acid0.9%44
9
Bicalutamide0.7%37
10
Carboplatin0.5%24
11
Olaparib0.5%23
12
Apalutamide0.3%13
13
Prednisolone0.2%11
14
Rucaparib-camsylate0.2%11
15
Degarelix-acetate0.2%10

Taken alongside

1
Denosumab4.7%240
2
Abiraterone-acetate3.9%199
3
Leuprolide3.8%194
4
Enzalutamide3.6%185
5
Prednisone2.9%148
6
Acetaminophen2.2%113
7
Docetaxel2.2%112
8
Aspirin2.1%105
9
Oxycodone1.9%98
10
Zoledronic-acid1.8%91
11
Calcium1.7%89
12
Dexamethasone1.5%78
13
Bicalutamide1.5%76
14
Ergocalciferol1.5%76
15
Atorvastatin-calcium1.4%73

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports radium side effects

0.8% of radium adverse event reports involve female patients and 88.4% involve male patients. The largest age group is elderly at 79%. These figures reflect who reports side effects, not underlying risk.

Sex

Female0.8%
Male88.4%
Unknown10.7%

Age group

< 2<0.1%
2–11<0.1%
12–170.1%
18–6420.5%
65+79.3%

What is radium used for

Conditions and purposes for which patients were taking radium when the adverse event was reported.

Acute LeukaemiaAnaemia Of Malignant DiseaseAnalgesic TherapyArthralgiaAdenocarcinoma MetastaticBack PainBlood Alkaline Phosphatase IncreasedBone CancerBone Cancer MetastaticBone DisorderBone LesionBone PainBreast CancerBreast Cancer MetastaticBack Pain

Showing 15 of 83 indications

Radium brand names and reporting trend

Radium is sold under the brand name Xofigo.

Brand names

Xofigo381

Quarterly reports (20132025)

20132016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking radium with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.