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Rabeprazole Side Effects

The most commonly reported side effects of rabeprazole include chronic kidney disease, renal failure, and acute kidney injury, based on 37,968 FDA adverse event reports from 2004 to 2025. 5.7% of reports found the drug to be ineffective.

Rabeprazole side effects

Percentages show how often each reaction appears relative to total reports for rabeprazole.

1
Chronic Kidney Disease13.1%4,977
2
Renal Failure8.8%3,357
3
Acute Kidney Injury7.5%2,840
4
Drug Ineffective5.7%2,153
5
Off Label Use5.1%1,933
6
Nausea4.4%1,675
7
Pain4.2%1,579
8
Headache3.9%1,473
9
Fatigue3.7%1,413
10
Diarrhoea3.7%1,404
11
Arthralgia3.7%1,395
12
Death3.6%1,372
13
End Stage Renal Disease3.5%1,336
14
Dyspnoea3.5%1,330
15
Tubulointerstitial Nephritis3.1%1,161

These are voluntary reports and do not establish that rabeprazole caused these reactions.

Report severity

83.9%Serious31,847 reports
34.3%Hospitalizations13,018 reports
11.8%Fatal4,468 reports

Seriousness is determined by the reporter, not by OpenClaim.

Rabeprazole drug interactions

Other drugs that appear in adverse event reports alongside rabeprazole. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Omeprazole18.4%6,969
2
Lansoprazole17.4%6,605
3
Esomeprazole17.3%6,564
4
Pantoprazole-sodium16.5%6,266
5
Dexlansoprazole13.7%5,200
6
Naproxen11.5%4,378
7
Adalimumab4.5%1,700
8
Rituximab4.2%1,598
9
Prednisone3.1%1,169
10
Methotrexate3.1%1,161
11
Etanercept2.7%1,028
12
Infliximab2.5%964
13
Tocilizumab2.2%841
14
Acetaminophen1.9%729
15
Abatacept1.9%717

Taken alongside

1
Acetaminophen15.0%5,707
2
Aspirin14.0%5,300
3
Levothyroxine-sodium11.2%4,243
4
Furosemide10.8%4,099
5
Prednisone10.0%3,813
6
Atorvastatin-calcium9.8%3,709
7
Amlodipine9.7%3,693
8
Ergocalciferol9.0%3,423
9
Albuterol7.3%2,790
10
Hydrochlorothiazide7.2%2,729
11
Metformin7.1%2,698
12
Metoprolol6.9%2,607
13
Folic-acid6.5%2,463
14
Fluticasone6.3%2,396
15
Rosuvastatin6.2%2,372

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports rabeprazole side effects

51.1% of rabeprazole adverse event reports involve female patients and 31.5% involve male patients. The largest age group is adult at 51%. These figures reflect who reports side effects, not underlying risk.

Sex

Female51.1%
Male31.5%
Unknown17.4%

Age group

< 20.2%
2–110.2%
12–170.3%
18–6450.9%
65+48.4%

What is rabeprazole used for

Conditions and purposes for which patients were taking rabeprazole when the adverse event was reported.

17-alpha-hydroxylase DeficiencyAbdominal DiscomfortAbdominal DistensionAbdominal PainAbdominal Pain UpperAbdominal SymptomAcid Base Balance AbnormalAcid Peptic DiseaseAcid Reflux (esophageal)Acid Reflux (oesophageal)AcidosisAcquired Oesophageal WebAcute Coronary SyndromeAcute Myeloid LeukaemiaAdenocarcinoma Of Colon

Showing 15 of 459 indications

Rabeprazole brand names and reporting trend

Rabeprazole is sold under the brand name Aciphex Sprinkle.

Brand names

Aciphex Sprinkle26,449

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking rabeprazole with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.