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Quinupristin Side Effects

The most commonly reported side effects of quinupristin include sepsis, death, and thrombocytopenia, based on 117 FDA adverse event reports from 2004 to 2025. 4.3% of reports found the drug to be ineffective.

Quinupristin side effects

Percentages show how often each reaction appears relative to total reports for quinupristin.

1
Sepsis7.7%9
2
Death6.8%8
3
Thrombocytopenia5.1%6
4
Blood Bilirubin Increased5.1%6
5
Death5.1%6
6
Rash5.1%6
7
Anaemia4.3%5
8
Drug Ineffective4.3%5
9
Blood Creatinine Increased4.3%5
10
Nausea4.3%5
11
Pyrexia4.3%5
12
Myalgia4.3%5
13
Drug Ineffective4.3%5
14
Disseminated Intravascular Coagulation3.4%4
15
Platelet Count Decreased3.4%4

These are voluntary reports and do not establish that quinupristin caused these reactions.

Report severity

78.6%Serious92 reports
22.2%Hospitalizations26 reports
43.6%Fatal51 reports

Seriousness is determined by the reporter, not by OpenClaim.

Quinupristin drug interactions

Other drugs that appear in adverse event reports alongside quinupristin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Dalfopristin58.1%68
2
Daptomycin25.6%30
3
Vancomycin6.8%8
4
Linezolid6.0%7
5
Ceftriaxone-sodium5.1%6
6
Amphotericin-b4.3%5
7
Sulfamethoxazole4.3%5
8
Caspofungin-acetate3.4%4
9
Voriconazole3.4%4
10
Rifampin2.6%3
11
Clofarabine1.7%2
12
Telavancin1.7%2
13
Tacrolimus1.7%2
14
Trimethoprim1.7%2
15
Chloramphenicol1.7%2

Taken alongside

1
Dalfopristin39.3%46
2
Vancomycin19.7%23
3
Linezolid13.7%16
4
Pantoprazole-sodium9.4%11
5
Furosemide8.5%10
6
Cefepime-hydrochloride8.5%10
7
Insulin8.5%10
8
Acetaminophen7.7%9
9
Heparin7.7%9
10
Aspirin6.8%8
11
Meropenem6.8%8
12
Metoprolol6.8%8
13
Fentanyl6.0%7
14
Levothyroxine-sodium6.0%7
15
Ciprofloxacin5.1%6

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports quinupristin side effects

36.8% of quinupristin adverse event reports involve female patients and 44.4% involve male patients. The largest age group is adult at 57%. These figures reflect who reports side effects, not underlying risk.

Sex

Female36.8%
Male44.4%
Unknown18.8%

Age group

< 20.0%
2–116.3%
12–175.1%
18–6457.0%
65+31.6%

What is quinupristin used for

Conditions and purposes for which patients were taking quinupristin when the adverse event was reported.

Abdominal Wall AbscessAbscessActinomycosisArthritis BacterialBacterial InfectionCystic FibrosisDevice Related InfectionDrug Use For Unknown IndicationEndocarditisEndocarditis EnterococcalEndocarditis StaphylococcalEnterococcal InfectionGlycopeptide Antibiotic Resistant Enterococcal InfectionGroin AbscessInfection

Showing 15 of 30 indications

Quinupristin brand names and reporting trend

Quinupristin is sold under the brand name Synercid.

Brand names

Synercid8

Quarterly reports (20042025)

200520102020

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking quinupristin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.