OpenClaim

Propranolol Side Effects

The most commonly reported side effects of propranolol include off label use, nausea, and fatigue, based on 72,175 FDA adverse event reports from 2004 to 2025. 7.0% of reports found the drug to be ineffective.

Propranolol side effects

Percentages show how often each reaction appears relative to total reports for propranolol.

1
Off Label Use10.2%7,359
2
Drug Ineffective7.0%5,039
3
Nausea5.2%3,769
4
Fatigue4.9%3,503
5
Headache4.7%3,410
6
Product Use In Unapproved Indication4.0%2,911
7
Diarrhoea3.9%2,848
8
Dizziness3.7%2,669
9
Product Use Issue3.5%2,558
10
Vomiting3.2%2,285
11
Toxicity To Various Agents3.1%2,239
12
Dyspnoea3.0%2,145
13
Pain2.8%2,018
14
Insomnia2.7%1,920
15
Fall2.6%1,889

These are voluntary reports and do not establish that propranolol caused these reactions.

Report severity

70.2%Serious50,658 reports
30.9%Hospitalizations22,285 reports
10.2%Fatal7,361 reports

Seriousness is determined by the reporter, not by OpenClaim.

Propranolol drug interactions

Other drugs that appear in adverse event reports alongside propranolol. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Sodium-oxybate3.8%2,708
2
Topiramate3.3%2,413
3
Acetaminophen3.2%2,303
4
Venlafaxine2.8%2,023
5
Quetiapine-fumarate2.6%1,893
6
Adalimumab2.5%1,820
7
Gabapentin2.4%1,725
8
Sertraline-hydrochloride2.4%1,710
9
Omeprazole2.2%1,611
10
Pregabalin2.2%1,561
11
Duloxetine-hydrochloride2.0%1,409
12
Amitriptyline-hydrochloride2.0%1,408
13
Tramadol-hydrochloride1.8%1,287
14
Hydrochlorothiazide1.6%1,156
15
Lamotrigine1.6%1,119

Taken alongside

1
Acetaminophen11.0%7,941
2
Omeprazole9.7%6,981
3
Levothyroxine-sodium9.1%6,604
4
Ergocalciferol8.9%6,416
5
Aspirin8.3%6,009
6
Gabapentin7.8%5,605
7
Atorvastatin-calcium6.2%4,464
8
Furosemide6.2%4,455
9
Metformin5.6%4,047
10
Pantoprazole-sodium5.5%3,960
11
Albuterol5.4%3,919
12
Amlodipine5.4%3,866
13
Clonazepam4.8%3,471
14
Hydrochlorothiazide4.8%3,450
15
Lisinopril4.5%3,238

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports propranolol side effects

60.3% of propranolol adverse event reports involve female patients and 30.0% involve male patients. The largest age group is adult at 64%. These figures reflect who reports side effects, not underlying risk.

Sex

Female60.3%
Male30.0%
Unknown9.7%

Age group

< 25.4%
2–111.3%
12–171.6%
18–6464.0%
65+27.6%

What is propranolol used for

Conditions and purposes for which patients were taking propranolol when the adverse event was reported.

Abdominal DiscomfortAbdominal MigraineAbnormal BehaviourAccidental ExposureAccidental Exposure To ProductAccidental OverdoseAction TremorAcute Coronary SyndromeAcute Myocardial InfarctionAcute Pulmonary OedemaAdcy5-related DyskinesiaAdjustment DisorderAdjustment Disorder With Mixed Anxiety And Depressed MoodAdjuvant TherapyAdrenal Disorder

Showing 15 of 1,253 indications

Propranolol brand names and reporting trend

Propranolol is sold under the brand name Innopran Xl.

Brand names

Innopran Xl208

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking propranolol with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.