OpenClaim

Propantheline Side Effects

The most commonly reported side effects of propantheline include dyspnoea, hyponatraemia, and diarrhoea, based on 263 FDA adverse event reports from 2004 to 2025. 3.4% of reports found the drug to be ineffective.

Propantheline side effects

Percentages show how often each reaction appears relative to total reports for propantheline.

1
Dyspnoea5.3%14
2
Hyponatraemia4.6%12
3
Diarrhoea3.8%10
4
Malaise3.8%10
5
Hip Fracture3.4%9
6
Pyrexia3.4%9
7
Drug Ineffective3.4%9
8
Off Label Use3.4%9
9
Dizziness3.4%9
10
Hyperhidrosis3.0%8
11
Drug Interaction3.0%8
12
Epistaxis3.0%8
13
Abdominal Pain2.7%7
14
Erythema2.7%7
15
Tachycardia2.7%7

These are voluntary reports and do not establish that propantheline caused these reactions.

Report severity

81.7%Serious215 reports
39.5%Hospitalizations104 reports
6.8%Fatal18 reports

Seriousness is determined by the reporter, not by OpenClaim.

Propantheline drug interactions

Other drugs that appear in adverse event reports alongside propantheline. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Clozapine5.7%15
2
Aspirin5.7%15
3
Acetaminophen5.3%14
4
Propoxyphene4.9%13
5
Cephalexin4.6%12
6
Famotidine4.2%11
7
Prednisone4.2%11
8
Enoxaparin-sodium3.8%10
9
Albuterol3.8%10
10
Spironolactone3.4%9
11
Tramadol-hydrochloride3.4%9
12
Mirtazapine3.4%9
13
Fluticasone3.4%9
14
Gabapentin3.4%9
15
Amlodipine3.0%8

Taken alongside

1
Lansoprazole14.8%39
2
Omeprazole14.4%38
3
Aspirin14.1%37
4
Acetaminophen13.3%35
5
Atorvastatin-calcium13.3%35
6
Albuterol12.5%33
7
Furosemide11.8%31
8
Amlodipine11.0%29
9
Pyridostigmine-bromide11.0%29
10
Metformin8.7%23
11
Amitriptyline-hydrochloride8.7%23
12
Citalopram-hydrobromide8.0%21
13
Simvastatin8.0%21
14
Venlafaxine7.6%20
15
Hydrochlorothiazide7.6%20

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports propantheline side effects

58.2% of propantheline adverse event reports involve female patients and 36.1% involve male patients. The largest age group is adult at 50%. These figures reflect who reports side effects, not underlying risk.

Sex

Female58.2%
Male36.1%
Unknown5.7%

Age group

< 20.5%
2–111.5%
12–170.0%
18–6450.3%
65+47.7%

What is propantheline used for

Conditions and purposes for which patients were taking propantheline when the adverse event was reported.

Abdominal DiscomfortAbdominal PainBack PainChronic Obstructive Pulmonary DiseaseColitis UlcerativeColitis UlcerativeDrug Use For Unknown IndicationDefaecation UrgencyFlatulenceFoetal Exposure During PregnancyGastric DisorderGastritis ProphylaxisGastrooesophageal Reflux DiseaseGastrointestinal DisorderHyperhidrosis

Showing 15 of 35 indications

Propantheline brand names and reporting trend

Propantheline is sold under the brand name Pro-banthine.

Brand names

Pro-banthine233

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking propantheline with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.