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Propafenone Side Effects

The most commonly reported side effects of propafenone include atrial fibrillation, drug interaction, and dizziness, based on 8,270 FDA adverse event reports from 2004 to 2025. 5.5% of reports found the drug to be ineffective.

Propafenone side effects

Percentages show how often each reaction appears relative to total reports for propafenone.

1
Atrial Fibrillation5.8%477
2
Drug Ineffective5.5%456
3
Drug Interaction4.3%354
4
Dizziness3.9%321
5
Dyspnoea3.7%306
6
Atrial Fibrillation3.6%301
7
Fatigue3.5%289
8
Nausea3.1%255
9
Toxicity To Various Agents3.0%245
10
Asthenia2.9%239
11
Off Label Use2.9%236
12
Diarrhoea2.7%222
13
Dizziness2.5%210
14
Fall2.5%209
15
Drug Ineffective2.2%185

These are voluntary reports and do not establish that propafenone caused these reactions.

Report severity

76.3%Serious6,309 reports
41.4%Hospitalizations3,420 reports
10.4%Fatal857 reports

Seriousness is determined by the reporter, not by OpenClaim.

Propafenone drug interactions

Other drugs that appear in adverse event reports alongside propafenone. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Dabigatran-etexilate-mesylate5.4%444
2
Rivaroxaban4.2%346
3
Metoprolol3.3%272
4
Apixaban2.9%236
5
Aspirin2.6%219
6
Warfarin2.5%208
7
Lenalidomide2.3%191
8
Atorvastatin-calcium1.8%147
9
Amiodarone-hydrochloride1.7%140
10
Omeprazole1.6%132
11
Digoxin1.5%126
12
Adalimumab1.5%123
13
Bisoprolol-fumarate1.5%123
14
Metformin1.2%102
15
Hydrochlorothiazide1.1%94

Taken alongside

1
Aspirin13.6%1,127
2
Metoprolol13.3%1,100
3
Levothyroxine-sodium11.3%932
4
Furosemide10.6%873
5
Warfarin9.8%810
6
Atorvastatin-calcium8.8%729
7
Omeprazole7.8%641
8
Acetaminophen7.6%630
9
Ergocalciferol7.3%604
10
Amlodipine6.7%552
11
Diltiazem6.6%544
12
Simvastatin6.5%535
13
Lisinopril6.0%495
14
Apixaban5.8%480
15
Pantoprazole-sodium5.5%457

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports propafenone side effects

54.9% of propafenone adverse event reports involve female patients and 38.3% involve male patients. The largest age group is elderly at 64%. These figures reflect who reports side effects, not underlying risk.

Sex

Female54.9%
Male38.3%
Unknown6.8%

Age group

< 21.4%
2–111.0%
12–171.3%
18–6432.7%
65+63.6%

What is propafenone used for

Conditions and purposes for which patients were taking propafenone when the adverse event was reported.

Accidental Exposure To ProductAccidental Exposure To Product By ChildAccidental OverdoseAfibAnaemiaAngina PectorisAnxietyArrhythmiaArrhythmia ProphylaxisArrhythmia SupraventricularAtrial FibrillationAtrial FlutterAtrial Septal DefectAtrial TachycardiaAtrioventricular Conduction Time Shortened

Showing 15 of 198 indications

Propafenone brand names and reporting trend

Propafenone is sold under the brand name Rythmol Sr.

Brand names

Rythmol Sr546

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking propafenone with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.