OpenClaim

Promazine Side Effects

The most commonly reported side effects of promazine include drug interaction, sopor, and suicide attempt, based on 1,090 FDA adverse event reports from 2004 to 2025. 3.2% of reports found the drug to be ineffective.

Promazine side effects

Percentages show how often each reaction appears relative to total reports for promazine.

1
Drug Interaction8.4%92
2
Sopor5.7%62
3
Suicide Attempt5.7%62
4
Overdose5.5%60
5
Electrocardiogram Qt Prolonged5.2%57
6
Off Label Use4.9%53
7
Drug Abuse4.6%50
8
Intentional Overdose4.5%49
9
Toxicity To Various Agents4.1%45
10
Neuroleptic Malignant Syndrome3.8%41
11
Intentional Self-injury3.8%41
12
Hypotension3.8%41
13
Somnolence3.6%39
14
Suicidal Ideation3.4%37
15
Psychotic Disorder3.4%37

These are voluntary reports and do not establish that promazine caused these reactions.

Report severity

96.8%Serious1,055 reports
48.0%Hospitalizations523 reports
16.3%Fatal178 reports

Seriousness is determined by the reporter, not by OpenClaim.

Promazine drug interactions

Other drugs that appear in adverse event reports alongside promazine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Haloperidol14.8%161
2
Quetiapine-fumarate11.7%127
3
Olanzapine10.5%114
4
Diazepam9.4%102
5
Risperidone9.2%100
6
Clozapine8.1%88
7
Lorazepam7.2%78
8
Citalopram-hydrobromide4.8%52
9
Fluoxetine-hydrochloride4.1%45
10
Mirtazapine3.9%42
11
Venlafaxine3.8%41
12
Alprazolam3.8%41
13
Aripiprazole3.7%40
14
Carbamazepine3.6%39
15
Furosemide3.6%39

Taken alongside

1
Lorazepam8.3%90
2
Acetaminophen7.8%85
3
Omeprazole7.1%77
4
Aspirin6.0%65
5
Diazepam5.9%64
6
Furosemide5.8%63
7
Zolpidem-tartrate4.5%49
8
Haloperidol4.4%48
9
Bisoprolol-fumarate4.3%47
10
Eszopiclone4.0%44
11
Enoxaparin-sodium4.0%44
12
Pantoprazole-sodium3.5%38
13
Clonazepam3.4%37
14
Gabapentin3.4%37
15
Sertraline-hydrochloride3.2%35

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports promazine side effects

49.6% of promazine adverse event reports involve female patients and 42.9% involve male patients. The largest age group is adult at 68%. These figures reflect who reports side effects, not underlying risk.

Sex

Female49.6%
Male42.9%
Unknown7.4%

Age group

< 20.9%
2–111.0%
12–172.7%
18–6467.9%
65+27.5%

What is promazine used for

Conditions and purposes for which patients were taking promazine when the adverse event was reported.

Abnormal BehaviourAggressionAgitationAntiemetic Supportive CareAnxietyAdverse EventAffective DisorderAgitationAntiemetic Supportive CareAnxiety DisorderBipolar DisorderBipolar I DisorderBorderline Personality DisorderBipolar I DisorderBipolar Disorder

Showing 15 of 100 indications

Promazine brand names and reporting trend

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking promazine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.