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Procyclidine Side Effects

The most commonly reported side effects of procyclidine include vomiting, schizophrenia, and psychotic disorder, based on 2,445 FDA adverse event reports from 2004 to 2025.

Procyclidine side effects

Percentages show how often each reaction appears relative to total reports for procyclidine.

1
Vomiting15.3%373
2
Schizophrenia13.2%322
3
Psychotic Disorder11.0%269
4
Pneumonia10.9%266
5
Nausea10.0%244
6
Off Label Use9.2%224
7
Cholelithiasis9.0%219
8
Drug Interaction8.8%216
9
Condition Aggravated8.7%213
10
Toxicity To Various Agents8.3%202
11
Confusional State7.6%185
12
Jaundice Cholestatic6.5%160
13
Hepatic Enzyme Increased6.5%160
14
Blood Bilirubin Increased6.3%155
15
Neuroleptic Malignant Syndrome6.3%153

These are voluntary reports and do not establish that procyclidine caused these reactions.

Report severity

98.5%Serious2,408 reports
56.2%Hospitalizations1,374 reports
14.6%Fatal357 reports

Seriousness is determined by the reporter, not by OpenClaim.

Procyclidine drug interactions

Other drugs that appear in adverse event reports alongside procyclidine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Clozapine25.3%619
2
Risperidone19.0%464
3
Quetiapine-fumarate18.9%461
4
Olanzapine18.5%452
5
Diazepam15.7%383
6
Clonazepam11.5%281
7
Aripiprazole11.2%273
8
Acetaminophen10.6%259
9
Carbamazepine10.3%253
10
Trazodone-hydrochloride9.5%233
11
Divalproex-sodium8.7%213
12
Tipranavir8.4%206
13
Mirtazapine7.0%171
14
Haloperidol6.9%169
15
Sertraline-hydrochloride6.4%156

Taken alongside

1
Lactulose13.1%320
2
Acetaminophen12.7%311
3
Lithium12.2%299
4
Sertraline-hydrochloride11.0%268
5
Lorazepam10.8%265
6
Omeprazole9.8%240
7
Loperamide-hydrochloride9.4%230
8
Diazepam9.0%220
9
Haloperidol8.8%215
10
Bisacodyl8.6%210
11
Calcium-carbonate8.5%208
12
Atorvastatin-calcium8.2%200
13
Lopinavir8.0%196
14
Ritonavir8.0%196
15
Nystatin8.0%196

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports procyclidine side effects

45.9% of procyclidine adverse event reports involve female patients and 43.7% involve male patients. The largest age group is adult at 84%. These figures reflect who reports side effects, not underlying risk.

Sex

Female45.9%
Male43.7%
Unknown10.4%

Age group

< 20.6%
2–110.0%
12–172.2%
18–6484.1%
65+13.0%

What is procyclidine used for

Conditions and purposes for which patients were taking procyclidine when the adverse event was reported.

Adverse Drug ReactionAdverse EventAdverse ReactionAgitationAkathisiaAkinesiaAnticholinergic SyndromeAnxiety DisorderArthralgiaAsperger^s DisorderAutism Spectrum DisorderAdverse Drug ReactionAdverse ReactionAggressionAkathisia

Showing 15 of 101 indications

Procyclidine brand names and reporting trend

Procyclidine is sold under the brand name Kemadrin.

Brand names

Kemadrin3,014

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking procyclidine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.