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Prochlorperazine Side Effects

The most commonly reported side effects of prochlorperazine include nausea, fatigue, and diarrhoea, based on 57,312 FDA adverse event reports from 2004 to 2025.

Prochlorperazine side effects

Percentages show how often each reaction appears relative to total reports for prochlorperazine.

1
Nausea11.1%6,372
2
Fatigue10.0%5,734
3
Diarrhoea7.9%4,541
4
Death6.2%3,574
5
Vomiting5.9%3,392
6
Off Label Use4.5%2,553
7
Asthenia4.4%2,508
8
Febrile Neutropenia3.9%2,260
9
Decreased Appetite3.8%2,197
10
Dyspnoea3.8%2,162
11
Pneumonia3.6%2,049
12
Constipation3.5%1,978
13
Pain3.4%1,958
14
Headache3.4%1,922
15
Pyrexia3.1%1,805

These are voluntary reports and do not establish that prochlorperazine caused these reactions.

Report severity

74.6%Serious42,768 reports
42.7%Hospitalizations24,492 reports
14.7%Fatal8,432 reports

Seriousness is determined by the reporter, not by OpenClaim.

Prochlorperazine drug interactions

Other drugs that appear in adverse event reports alongside prochlorperazine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Lenalidomide14.6%8,394
2
Pomalidomide3.5%2,017
3
Venetoclax3.2%1,811
4
Capecitabine3.1%1,766
5
Paclitaxel3.1%1,753
6
Docetaxel3.0%1,728
7
Carboplatin2.9%1,684
8
Bevacizumab2.9%1,679
9
Cyclophosphamide2.8%1,631
10
Dexamethasone2.3%1,299
11
Nivolumab2.2%1,281
12
Rituximab2.2%1,260
13
Doxorubicin-hydrochloride2.1%1,228
14
Gemcitabine2.0%1,160
15
Prednisone2.0%1,132

Taken alongside

1
Ondansetron41.0%23,517
2
Acetaminophen33.6%19,249
3
Dexamethasone26.1%14,931
4
Aspirin20.7%11,838
5
Acyclovir20.4%11,696
6
Oxycodone19.7%11,273
7
Lorazepam18.9%10,847
8
Omeprazole18.5%10,596
9
Ergocalciferol17.1%9,823
10
Levothyroxine-sodium15.0%8,583
11
Pantoprazole-sodium14.5%8,325
12
Gabapentin13.5%7,752
13
Albuterol13.3%7,594
14
Amlodipine12.8%7,345
15
Furosemide12.8%7,310

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports prochlorperazine side effects

54.4% of prochlorperazine adverse event reports involve female patients and 39.0% involve male patients. The largest age group is adult at 51%. These figures reflect who reports side effects, not underlying risk.

Sex

Female54.4%
Male39.0%
Unknown6.7%

Age group

< 20.1%
2–110.1%
12–170.4%
18–6451.4%
65+48.0%

What is prochlorperazine used for

Conditions and purposes for which patients were taking prochlorperazine when the adverse event was reported.

Abdominal DiscomfortAbdominal PainAbdominal Pain UpperAcoustic NeuromaAcute Graft Versus Host DiseaseAcute Myeloid LeukaemiaAdverse EventAlopeciaAmnesiaAnaemiaAngioimmunoblastic T-cell LymphomaAntiallergic TherapyAntidepressant TherapyAntiemetic Supportive CareAntifungal Prophylaxis

Showing 15 of 349 indications

Prochlorperazine brand names and reporting trend

Prochlorperazine is sold under brand names including Compazine, Prochlorperazine.

Brand names

Compazine38,880
Prochlorperazine2,864

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking prochlorperazine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.