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Procarbazine Side Effects

The most commonly reported side effects of procarbazine include nausea, fatigue, and vomiting, based on 7,855 FDA adverse event reports from 2004 to 2025. 2.7% of reports found the drug to be ineffective.

Procarbazine side effects

Percentages show how often each reaction appears relative to total reports for procarbazine.

1
Nausea13.5%1,060
2
Fatigue11.5%907
3
Vomiting4.9%385
4
Off Label Use4.4%345
5
Neutropenia4.3%341
6
Constipation3.6%286
7
Platelet Count Decreased3.2%253
8
White Blood Cell Count Decreased3.1%243
9
Thrombocytopenia3.0%233
10
Headache2.9%227
11
Disease Progression2.8%221
12
Drug Ineffective2.7%214
13
Acute Myeloid Leukaemia2.6%202
14
Decreased Appetite2.6%201
15
Pyrexia2.4%188

These are voluntary reports and do not establish that procarbazine caused these reactions.

Report severity

57.5%Serious4,515 reports
20.2%Hospitalizations1,585 reports
16.9%Fatal1,331 reports

Seriousness is determined by the reporter, not by OpenClaim.

Procarbazine drug interactions

Other drugs that appear in adverse event reports alongside procarbazine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Vincristine-sulfate37.4%2,940
2
Doxorubicin-hydrochloride26.1%2,052
3
Cyclophosphamide23.9%1,881
4
Etoposide23.9%1,879
5
Prednisone23.1%1,816
6
Bleomycin-sulfate22.2%1,747
7
Rituximab12.3%968
8
Methotrexate11.6%912
9
Vinblastine-sulfate10.3%808
10
Prednisolone8.6%677
11
Cytarabine7.2%564
12
Dacarbazine7.1%559
13
Dexamethasone5.3%418
14
Lomustine4.9%388
15
Cisplatin3.7%290

Taken alongside

1
Levetiracetam8.7%682
2
Lomustine6.9%541
3
Ondansetron6.8%537
4
Vincristine-sulfate6.5%514
5
Prednisone5.3%416
6
Acetaminophen3.6%279
7
Dexamethasone3.5%271
8
Cyclophosphamide3.2%254
9
Etoposide2.7%209
10
Omeprazole2.4%187
11
Sulfamethoxazole2.4%187
12
Ergocalciferol2.4%187
13
Acyclovir2.3%180
14
Doxorubicin-hydrochloride2.2%171
15
Trimethoprim2.1%167

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports procarbazine side effects

35.5% of procarbazine adverse event reports involve female patients and 45.2% involve male patients. The largest age group is adult at 69%. These figures reflect who reports side effects, not underlying risk.

Sex

Female35.5%
Male45.2%
Unknown19.3%

Age group

< 20.9%
2–112.6%
12–174.4%
18–6469.2%
65+22.9%

What is procarbazine used for

Conditions and purposes for which patients were taking procarbazine when the adverse event was reported.

Acute Lymphocytic LeukaemiaAcute Myeloid LeukaemiaAcute Promyelocytic LeukaemiaAdult T-cell Lymphoma/leukaemiaAnaplastic AstrocytomaAnaplastic Large Cell Lymphoma T- And Null-cell TypesAnaplastic Large-cell LymphomaAnaplastic OligodendrogliomaAngiocentric LymphomaAngioimmunoblastic T-cell LymphomaAstrocytomaAstrocytoma MalignantAstrocytoma, Low GradeAdrenal Gland CancerAdult T-cell Lymphoma/leukaemia Stage Iv

Showing 15 of 322 indications

Procarbazine brand names and reporting trend

Procarbazine is sold under the brand name Matulane.

Brand names

Matulane4,506

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking procarbazine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.