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Procaine Side Effects

The most commonly reported side effects of procaine include drug hypersensitivity, dizziness, and atrial fibrillation, based on 955 FDA adverse event reports from 2004 to 2025. 5.0% of reports found the drug to be ineffective.

Procaine side effects

Percentages show how often each reaction appears relative to total reports for procaine.

1
Drug Hypersensitivity19.9%190
2
Dizziness5.8%55
3
Atrial Fibrillation5.8%55
4
Drug Ineffective5.0%48
5
Post Procedural Complication5.0%48
6
Pain3.7%35
7
Fatigue3.6%34
8
Off Label Use3.5%33
9
Nausea3.2%31
10
Headache3.1%30
11
Drug Interaction3.1%30
12
Dyspnoea2.7%26
13
Feeling Abnormal2.5%24
14
Asthenia2.5%24
15
Malaise2.4%23

These are voluntary reports and do not establish that procaine caused these reactions.

Report severity

63.4%Serious605 reports
23.0%Hospitalizations220 reports
9.7%Fatal93 reports

Seriousness is determined by the reporter, not by OpenClaim.

Procaine drug interactions

Other drugs that appear in adverse event reports alongside procaine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Acetaminophen9.8%94
2
Lidocaine8.0%76
3
Fentanyl7.5%72
4
Dihydrocodeine-bitartrate6.3%60
5
Propofol5.0%48
6
Ketamine-hydrochloride4.9%47
7
Sevoflurane4.9%47
8
Morphine-sulfate4.2%40
9
Epinephrine4.2%40
10
Ibuprofen3.5%33
11
Ranibizumab3.4%32
12
Gabapentin3.1%30
13
Erythromycin3.0%29
14
Tramadol-hydrochloride2.8%27
15
Ciprofloxacin2.8%27

Taken alongside

1
Acetaminophen7.4%71
2
Aspirin6.5%62
3
Furosemide5.9%56
4
Ergocalciferol5.0%48
5
Levothyroxine-sodium4.6%44
6
Hydrocortisone4.4%42
7
Atorvastatin-calcium4.4%42
8
Lidocaine4.3%41
9
Prednisone4.3%41
10
Omeprazole3.6%34
11
Povidone-iodine3.6%34
12
Alprazolam3.6%34
13
Tetracycline3.5%33
14
Dexamethasone3.4%32
15
Metoprolol3.1%30

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports procaine side effects

57.6% of procaine adverse event reports involve female patients and 25.8% involve male patients. The largest age group is adult at 54%. These figures reflect who reports side effects, not underlying risk.

Sex

Female57.6%
Male25.8%
Unknown16.6%

Age group

< 21.4%
2–110.3%
12–171.5%
18–6453.8%
65+43.0%

What is procaine used for

Conditions and purposes for which patients were taking procaine when the adverse event was reported.

AcneAlopeciaAnaesthesiaAnaesthesia ProcedureAnaesthetic PremedicationAnalgesic TherapyAntibiotic TherapyArteriogram CoronaryArthralgiaAspiration Bone MarrowAspiration Pleural CavityAbdominal PanniculectomyAcute LeukaemiaAnaesthesiaAnaesthesia Procedure

Showing 15 of 125 indications

Procaine brand names and reporting trend

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking procaine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.