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Probucol Side Effects

The most commonly reported side effects of probucol include disease progression, type iia hyperlipidaemia, and liver injury, based on 308 FDA adverse event reports from 2004 to 2025. 2.3% of reports found the drug to be ineffective.

#1 Reported: Disease ProgressionAll side effects ↓Top Co-Medication: Atorvastatin-calciumDrug interactions ↓52% of Reports Are AdultDemographics ↓

Probucol side effects

Percentages show how often each reaction appears relative to total reports for probucol.

1
Disease Progression18.8%58
2
Type Iia Hyperlipidaemia18.2%56
3
Liver Injury5.5%17
4
Abdominal Pain4.9%15
5
Cholecystitis Acute4.5%14
6
Pleural Effusion4.2%13
7
Hypotension4.2%13
8
Nausea4.2%13
9
Drug Interaction2.9%9
10
Blood Creatine Phosphokinase Increased2.6%8
11
Cardiac Failure2.6%8
12
Diarrhoea2.6%8
13
Pneumonia2.3%7
14
Drug Ineffective2.3%7
15
Malaise1.9%6

These are voluntary reports and do not establish that probucol caused these reactions.

Report severity

95.8%Serious295 reports
52.6%Hospitalizations162 reports
27.9%Fatal86 reports

Seriousness is determined by the reporter, not by OpenClaim.

Probucol drug interactions

Other drugs that appear in adverse event reports alongside probucol. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Atorvastatin-calcium24.7%76
2
Cilostazol23.1%71
3
Rosuvastatin23.1%71
4
Evolocumab22.4%69
5
Simvastatin20.5%63
6
Lomitapide-mesylate19.8%61
7
Ezetimibe18.8%58
8
Lovastatin18.5%57
9
Aspirin16.6%51
10
Valsartan2.3%7
11
Prednisolone1.9%6
12
Telmisartan1.6%5
13
Clarithromycin1.3%4
14
Famotidine1.3%4
15
Fenofibrate1.3%4

Taken alongside

1
Aspirin17.2%53
2
Atorvastatin-calcium15.6%48
3
Amlodipine14.0%43
4
Furosemide9.4%29
5
Ezetimibe7.1%22
6
Gemfibrozil6.5%20
7
Clopidogrel-bisulfate6.2%19
8
Metoprolol6.2%19
9
Simvastatin5.5%17
10
Pantoprazole-sodium5.5%17
11
Rosuvastatin5.2%16
12
Acetaminophen5.2%16
13
Nifedipine4.9%15
14
Glimepiride4.9%15
15
Potassium-chloride4.9%15

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports probucol side effects

32.1% of probucol adverse event reports involve female patients and 47.1% involve male patients. The largest age group is adult at 52%. These figures reflect who reports side effects, not underlying risk.

Sex

Female32.1%
Male47.1%
Unknown20.8%

Age group

< 20.9%
2–111.3%
12–170.9%
18–6451.9%
65+45.0%

What is probucol used for

Conditions and purposes for which patients were taking probucol when the adverse event was reported.

Angina PectorisArteriosclerosisArteriosclerosis Coronary ArteryArteriosclerosis ObliteransBlood Cholesterol IncreasedBrachytherapy To SkinCardiomegalyCerebral InfarctionCoronary Artery DiseaseCerebral InfarctionDiabetic NephropathyDrug Use For Unknown IndicationDyslipidaemiaDyslipidaemiaHypercholesterolaemia

Showing 15 of 32 indications

Probucol brand names and reporting trend

Probucol is sold under the brand name Lorelco.

Brand names

Lorelco286

Quarterly reports (2004–2025)

2005201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking probucol with another medication?

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