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Probenecid Side Effects

The most commonly reported side effects of probenecid include diarrhoea, off label use, and adenovirus infection, based on 1,443 FDA adverse event reports from 2004 to 2025. 4.2% of reports found the drug to be ineffective.

Probenecid side effects

Percentages show how often each reaction appears relative to total reports for probenecid.

1
Diarrhoea6.5%94
2
Off Label Use4.4%63
3
Drug Ineffective4.2%61
4
Adenovirus Infection3.5%50
5
Acute Kidney Injury3.5%50
6
Toxicity To Various Agents3.0%44
7
Vomiting2.8%40
8
Fatigue2.6%37
9
Death2.6%37
10
Dyspnoea2.4%35
11
Nausea2.3%33
12
Chronic Kidney Disease2.1%31
13
Multiple Organ Dysfunction Syndrome2.1%30
14
Renal Failure2.0%29
15
Pain2.0%29

These are voluntary reports and do not establish that probenecid caused these reactions.

Report severity

72.7%Serious1,049 reports
37.1%Hospitalizations536 reports
14.5%Fatal209 reports

Seriousness is determined by the reporter, not by OpenClaim.

Probenecid drug interactions

Other drugs that appear in adverse event reports alongside probenecid. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Cidofovir7.8%112
2
Colchicine7.5%108
3
Lenalidomide3.1%45
4
Tacrolimus3.0%44
5
Adalimumab2.9%42
6
Omeprazole2.6%38
7
Prednisolone2.6%37
8
Furosemide2.5%36
9
Ruxolitinib2.4%35
10
Cyclophosphamide2.4%34
11
Ondansetron2.3%33
12
Cyclosporine2.1%30
13
Acetaminophen2.1%30
14
Fludarabine-phosphate2.1%30
15
Foscarnet-sodium2.1%30

Taken alongside

1
Aspirin20.9%301
2
Furosemide19.0%274
3
Acetaminophen15.3%221
4
Allopurinol12.9%186
5
Metoprolol12.6%182
6
Amlodipine12.1%174
7
Atorvastatin-calcium12.0%173
8
Colchicine11.4%165
9
Omeprazole10.5%152
10
Lisinopril10.2%147
11
Levothyroxine-sodium10.1%146
12
Ergocalciferol9.9%143
13
Gabapentin9.1%132
14
Prednisone9.1%131
15
Simvastatin8.5%123

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports probenecid side effects

30.5% of probenecid adverse event reports involve female patients and 62.8% involve male patients. The largest age group is elderly at 45%. These figures reflect who reports side effects, not underlying risk.

Sex

Female30.5%
Male62.8%
Unknown6.7%

Age group

< 21.0%
2–117.6%
12–173.0%
18–6443.4%
65+44.9%

What is probenecid used for

Conditions and purposes for which patients were taking probenecid when the adverse event was reported.

Abdominal PainAdenovirus InfectionArthritisAcute Kidney InjuryAcute Respiratory Distress SyndromeAdenovirus InfectionAnaemiaAntibiotic TherapyArthritis InfectiveBehcet^s SyndromeBk Polyomavirus Test PositiveBlood Uric AcidBlood Uric Acid AbnormalBlood Uric Acid IncreasedBlood Uric Acid

Showing 15 of 92 indications

Probenecid brand names and reporting trend

Probenecid is sold under the brand name Benemid.

Brand names

Benemid1,339

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking probenecid with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.