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Pretomanid Side Effects

The most commonly reported side effects of pretomanid include death, anaemia, and neuropathy peripheral, based on 599 FDA adverse event reports from 2013 to 2025. 2.5% of reports found the drug to be ineffective.

Pretomanid side effects

Percentages show how often each reaction appears relative to total reports for pretomanid.

1
Death17.4%104
2
Anaemia10.0%60
3
Neuropathy Peripheral8.3%50
4
Off Label Use8.2%49
5
Nausea5.8%35
6
Electrocardiogram Qt Prolonged5.5%33
7
Acute Kidney Injury4.2%25
8
Toxicity To Various Agents4.0%24
9
Hepatotoxicity3.7%22
10
Alanine Aminotransferase Increased3.5%21
11
Aspartate Aminotransferase Increased3.2%19
12
Optic Neuritis2.7%16
13
Vomiting2.5%15
14
Drug Ineffective2.5%15
15
Decreased Appetite2.5%15

These are voluntary reports and do not establish that pretomanid caused these reactions.

Report severity

98.5%Serious590 reports
23.2%Hospitalizations139 reports
43.2%Fatal259 reports

Seriousness is determined by the reporter, not by OpenClaim.

Pretomanid drug interactions

Other drugs that appear in adverse event reports alongside pretomanid. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Bedaquiline-fumarate85.5%512
2
Linezolid84.3%505
3
Moxifloxacin-hydrochloride48.9%293
4
Clofazimine19.7%118
5
Pyrazinamide5.2%31
6
Cycloserine4.0%24
7
Isoniazid2.7%16
8
Rifampin2.3%14
9
Aminosalicylic2.2%13
10
Amikacin-sulfate2.0%12
11
Meropenem2.0%12
12
Verapamil-hydrochloride1.5%9
13
Ethambutol-hydrochloride1.3%8
14
Pyridoxine1.2%7
15
Ethionamide0.8%5

Taken alongside

1
Pyridoxine18.0%108
2
Bedaquiline-fumarate12.5%75
3
Moxifloxacin-hydrochloride4.7%28
4
Bisoprolol-fumarate4.5%27
5
Atorvastatin-calcium4.3%26
6
Aspirin4.0%24
7
Dolutegravir3.7%22
8
Linezolid3.5%21
9
Folic-acid3.3%20
10
Lamivudine3.2%19
11
Metformin3.2%19
12
Amoxicillin3.0%18
13
Hydrochlorothiazide2.8%17
14
Metoprolol2.8%17
15
Enalapril-maleate2.7%16

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports pretomanid side effects

34.9% of pretomanid adverse event reports involve female patients and 57.4% involve male patients. The largest age group is adult at 73%. These figures reflect who reports side effects, not underlying risk.

Sex

Female34.9%
Male57.4%
Unknown7.7%

Age group

< 20.2%
2–110.0%
12–171.1%
18–6473.1%
65+25.6%

What is pretomanid used for

Conditions and purposes for which patients were taking pretomanid when the adverse event was reported.

Antibiotic ProphylaxisAntibiotic TherapyDisseminated Mycobacterium Avium Complex InfectionDisseminated TuberculosisHiv InfectionInfectionMeningitis TuberculousNauseaProduct Used For Unknown IndicationPulmonary TuberculosisProduct Used For Unknown IndicationPulmonary TuberculosisSmear TestTuberculosisTuberculosis

Showing 15 of 16 indications

Pretomanid brand names and reporting trend

Pretomanid is sold under the brand name Pretomanid.

Brand names

Pretomanid743

Quarterly reports (20132025)

2013202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking pretomanid with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.