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Pramlintide Side Effects

The most commonly reported side effects of pramlintide include blood glucose increased, nausea, and blood glucose decreased, based on 3,051 FDA adverse event reports from 2005 to 2025. 5.6% of reports found the drug to be ineffective.

#1 Reported: Blood Glucose IncreasedAll side effects ↓Top Co-Medication: InsulinDrug interactions ↓69% of Reports Are AdultDemographics ↓

Pramlintide side effects

Percentages show how often each reaction appears relative to total reports for pramlintide.

1
Blood Glucose Increased25.6%782
2
Nausea19.4%592
3
Blood Glucose Decreased10.1%309
4
Weight Decreased9.4%286
5
Injection Site Pain7.7%234
6
Decreased Appetite6.8%206
7
Drug Ineffective5.6%172
8
Blood Glucose Increased5.3%163
9
Fatigue4.4%135
10
Medication Error4.2%129
11
Vomiting3.8%115
12
Dizziness3.7%114
13
Diarrhoea3.6%110
14
Injection Site Bruising3.2%98
15
Hypoglycaemia3.2%97

These are voluntary reports and do not establish that pramlintide caused these reactions.

Report severity

20.4%Serious621 reports
10.1%Hospitalizations308 reports
1.3%Fatal40 reports

Seriousness is determined by the reporter, not by OpenClaim.

Pramlintide drug interactions

Other drugs that appear in adverse event reports alongside pramlintide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Insulin6.9%212
2
Exenatide-synthetic5.8%178
3
Metformin0.8%25
4
Esomeprazole0.8%25
5
Pioglitazone-hydrochloride0.7%20
6
Omeprazole0.7%20
7
Sodium-oxybate0.7%20
8
Pantoprazole-sodium0.6%19
9
Lansoprazole0.5%16
10
Sitagliptin0.5%15
11
Lisinopril0.4%11
12
Etanercept0.4%11
13
Liraglutide0.4%11
14
Canagliflozin0.4%11
15
Aspirin0.3%10

Taken alongside

1
Insulin67.3%2,054
2
Metformin17.9%545
3
Aspirin7.2%221
4
Levothyroxine-sodium6.3%193
5
Furosemide5.9%181
6
Atorvastatin-calcium5.4%166
7
Lisinopril5.0%153
8
Simvastatin4.6%139
9
Hydrochlorothiazide4.4%135
10
Pioglitazone-hydrochloride4.2%127
11
Metoprolol3.6%109
12
Exenatide-synthetic3.5%108
13
Amlodipine3.2%98
14
Glimepiride2.9%89
15
Rosiglitazone-maleate2.9%88

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports pramlintide side effects

64.7% of pramlintide adverse event reports involve female patients and 32.0% involve male patients. The largest age group is adult at 69%. These figures reflect who reports side effects, not underlying risk.

Sex

Female64.7%
Male32.0%
Unknown3.3%

Age group

< 20.1%
2–11<0.1%
12–170.5%
18–6469.4%
65+29.8%

What is pramlintide used for

Conditions and purposes for which patients were taking pramlintide when the adverse event was reported.

Antidepressant TherapyBlood GlucoseBlood Glucose AbnormalBlood Glucose FluctuationBlood Glucose IncreasedBlood Insulin IncreasedBlood Triglycerides IncreasedBlood Glucose IncreasedDecreased AppetiteDiabetes MellitusDiabetes Mellitus Insulin-dependentDiabetes Mellitus Malnutrition-relatedDiabetes Mellitus Non-insulin-dependentDrug Use For Unknown IndicationDumping Syndrome

Showing 15 of 47 indications

Pramlintide brand names and reporting trend

Pramlintide is sold under the brand name Symlin.

Brand names

Symlin49

Quarterly reports (2005–2025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking pramlintide with another medication?

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