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Pralidoxime Side Effects

The most commonly reported side effects of pralidoxime include substance-induced psychotic disorder, agitation, and accidental exposure, based on 72 FDA adverse event reports from 2004 to 2025. 8.3% of reports found the drug to be ineffective.

Pralidoxime side effects

Percentages show how often each reaction appears relative to total reports for pralidoxime.

1
Substance-induced Psychotic Disorder16.7%12
2
Agitation13.9%10
3
Accidental Exposure12.5%9
4
Product Use In Unapproved Indication11.1%8
5
Delirium8.3%6
6
Drug Ineffective8.3%6
7
Expired Drug Administered6.9%5
8
Mydriasis6.9%5
9
Obstructive Airways Disorder6.9%5
10
Hallucinations, Mixed6.9%5
11
Injection Site Injury5.6%4
12
Psychotic Disorder5.6%4
13
Toxicity To Various Agents5.6%4
14
Pupillary Light Reflex Tests Abnormal5.6%4
15
Anxiety5.6%4

These are voluntary reports and do not establish that pralidoxime caused these reactions.

Report severity

83.3%Serious60 reports
50.0%Hospitalizations36 reports
2.8%Fatal2 reports

Seriousness is determined by the reporter, not by OpenClaim.

Pralidoxime drug interactions

Other drugs that appear in adverse event reports alongside pralidoxime. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Atropine33.3%24
2
Midazolam11.1%8
3
Apomorphine-hydrochloride8.3%6
4
Diazepam8.3%6
5
Haloperidol6.9%5
6
Promethazine-hydrochloride5.6%4
7
Propofol5.6%4
8
Levetiracetam5.6%4
9
Lorazepam4.2%3
10
Tranexamic-acid4.2%3
11
Venlafaxine4.2%3
12
Alprazolam4.2%3
13
Phenytoin4.2%3
14
Magnesium-acetate-tetrahydrate4.2%3
15
Dexmedetomidine-hydrochloride2.8%2

Taken alongside

1
Atropine12.5%9
2
Pantoprazole-sodium12.5%9
3
Lorazepam8.3%6
4
Diazepam6.9%5
5
Ceftriaxone-sodium6.9%5
6
Midazolam5.6%4
7
Amlodipine5.6%4
8
Furosemide5.6%4
9
Methylprednisolone5.6%4
10
Epinephrine5.6%4
11
Acetaminophen5.6%4
12
Warfarin4.2%3
13
Theophylline4.2%3
14
Piperacillin4.2%3
15
Rocuronium-bromide4.2%3

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports pralidoxime side effects

36.1% of pralidoxime adverse event reports involve female patients and 56.9% involve male patients. The largest age group is adult at 66%. These figures reflect who reports side effects, not underlying risk.

Sex

Female36.1%
Male56.9%
Unknown6.9%

Age group

< 25.1%
2–113.4%
12–178.5%
18–6466.1%
65+16.9%

What is pralidoxime used for

Conditions and purposes for which patients were taking pralidoxime when the adverse event was reported.

Accidental PoisoningAnxietyAsthmaChemical PoisoningChemical PoisoningDepressionIntentional Self-injuryPoisoningProduct Used For Unknown IndicationPain ManagementProduct Used For Unknown IndicationPruritusRespiratory FailureRespiratory DepressionStatus Epilepticus

Showing 15 of 17 indications

Pralidoxime brand names and reporting trend

Pralidoxime is sold under the brand name Pralidoxime Chloride (autoinjector).

Brand names

Pralidoxime Chloride (autoinjector)73

Quarterly reports (20042025)

20042025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking pralidoxime with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.