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Povidone Side Effects

The most commonly reported side effects of povidone include off label use, endophthalmitis, and drug hypersensitivity, based on 4,782 FDA adverse event reports from 2004 to 2025. 4.9% of reports found the drug to be ineffective.

Povidone side effects

Percentages show how often each reaction appears relative to total reports for povidone.

1
Off Label Use9.8%470
2
Endophthalmitis8.1%388
3
Drug Hypersensitivity7.6%365
4
Drug Ineffective4.9%235
5
Nausea4.9%232
6
Toxic Anterior Segment Syndrome4.9%232
7
Rash4.6%222
8
Pain4.5%217
9
Eye Pain4.2%201
10
Vision Blurred3.9%186
11
Product Use In Unapproved Indication3.5%166
12
Visual Impairment3.2%152
13
Dyspnoea3.1%149
14
Visual Acuity Reduced3.0%145
15
Headache3.0%143

These are voluntary reports and do not establish that povidone caused these reactions.

Report severity

84.8%Serious4,057 reports
32.1%Hospitalizations1,535 reports
9.7%Fatal465 reports

Seriousness is determined by the reporter, not by OpenClaim.

Povidone drug interactions

Other drugs that appear in adverse event reports alongside povidone. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Sodium-chloride9.9%472
2
Potassium-chloride9.5%453
3
Calcium-chloride9.4%448
4
Magnesium-chloride9.4%448
5
Ranibizumab8.9%425
6
Sodium-citrate8.7%414
7
Sodium-acetate8.6%410
8
Dexamethasone7.2%345
9
Bevacizumab6.6%317
10
Lidocaine6.6%315
11
Aflibercept5.0%241
12
Methotrexate4.9%233
13
Triamcinolone4.9%232
14
Acetaminophen4.7%223
15
Diclofenac4.5%216

Taken alongside

1
Lidocaine10.8%517
2
Acetaminophen9.9%472
3
Proparacaine-hydrochloride6.2%298
4
Aspirin5.5%265
5
Dexamethasone5.4%257
6
Furosemide5.3%254
7
Sodium-chloride4.9%235
8
Prednisolone4.8%230
9
Potassium-chloride4.5%213
10
Amlodipine4.3%207
11
Levothyroxine-sodium4.3%207
12
Omeprazole4.2%200
13
Pantoprazole-sodium4.0%192
14
Calcium4.0%190
15
Metformin3.9%188

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports povidone side effects

53.7% of povidone adverse event reports involve female patients and 30.5% involve male patients. The largest age group is adult at 48%. These figures reflect who reports side effects, not underlying risk.

Sex

Female53.7%
Male30.5%
Unknown15.8%

Age group

< 22.5%
2–111.5%
12–171.1%
18–6448.2%
65+46.7%

What is povidone used for

Conditions and purposes for which patients were taking povidone when the adverse event was reported.

AbscessAccidental Exposure To ProductAccidental Exposure To Product Packaging By ChildAcute Myeloid LeukaemiaAge-related Macular DegenerationAmnesiaAnaesthesiaAnal FissureAnal PolypectomyAnorectal DisorderAnti-infective TherapyAntibacterial ProphylaxisAntibiotic ProphylaxisAntibiotic TherapyAntifungal Prophylaxis

Showing 15 of 312 indications

Povidone brand names and reporting trend

Povidone is sold under the brand name Betadine.

Brand names

Betadine1,894

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking povidone with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.