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Posaconazole Side Effects

The most commonly reported side effects of posaconazole include off label use, febrile neutropenia, and product use in unapproved indication, based on 15,601 FDA adverse event reports from 2004 to 2025. 9.0% of reports found the drug to be ineffective.

Posaconazole side effects

Percentages show how often each reaction appears relative to total reports for posaconazole.

1
Off Label Use10.0%1,557
2
Drug Ineffective9.0%1,404
3
Febrile Neutropenia6.4%991
4
Product Use In Unapproved Indication5.9%926
5
Death5.9%921
6
Drug Interaction5.5%855
7
Pyrexia5.3%824
8
Neutropenia4.3%669
9
Pneumonia4.1%637
10
Thrombocytopenia3.0%474
11
Diarrhoea3.0%473
12
Nausea3.0%461
13
Septic Shock2.7%415
14
Acute Kidney Injury2.7%415
15
Sepsis2.6%398

These are voluntary reports and do not establish that posaconazole caused these reactions.

Report severity

86.7%Serious13,523 reports
45.2%Hospitalizations7,049 reports
24.2%Fatal3,782 reports

Seriousness is determined by the reporter, not by OpenClaim.

Posaconazole drug interactions

Other drugs that appear in adverse event reports alongside posaconazole. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Venetoclax13.3%2,080
2
Cytarabine8.6%1,340
3
Azacitidine8.6%1,337
4
Amphotericin-b8.3%1,288
5
Tacrolimus6.2%975
6
Voriconazole5.9%928
7
Prednisone5.1%798
8
Mycophenolate4.9%766
9
Fludarabine-phosphate4.9%760
10
Cyclophosphamide4.8%746
11
Cyclosporine4.6%710
12
Ruxolitinib4.1%644
13
Dexamethasone3.7%584
14
Acyclovir3.5%545
15
Daunorubicin3.4%528

Taken alongside

1
Acyclovir23.7%3,700
2
Ondansetron11.5%1,799
3
Sulfamethoxazole10.0%1,559
4
Pantoprazole-sodium9.7%1,521
5
Acetaminophen9.7%1,518
6
Levofloxacin9.3%1,458
7
Allopurinol9.2%1,443
8
Prednisone9.0%1,405
9
Trimethoprim9.0%1,398
10
Omeprazole7.0%1,098
11
Furosemide6.9%1,074
12
Amphotericin-b6.7%1,052
13
Tacrolimus6.6%1,037
14
Amlodipine6.1%947
15
Potassium-chloride5.7%893

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports posaconazole side effects

35.7% of posaconazole adverse event reports involve female patients and 52.0% involve male patients. The largest age group is adult at 57%. These figures reflect who reports side effects, not underlying risk.

Sex

Female35.7%
Male52.0%
Unknown12.3%

Age group

< 20.6%
2–114.8%
12–174.4%
18–6456.7%
65+33.4%

What is posaconazole used for

Conditions and purposes for which patients were taking posaconazole when the adverse event was reported.

Abscess FungalAcanthamoeba InfectionAcanthamoeba KeratitisAcinetobacter InfectionAcute Graft Versus Host DiseaseAcute Graft Versus Host Disease OralAcute LeukaemiaAcute Lymphocytic LeukaemiaAcute Myeloid LeukaemiaAcute Myeloid Leukaemia (in Remission)Acute Myeloid Leukaemia RecurrentAcute Promyelocytic LeukaemiaAcute Pulmonary HistoplasmosisAdjuvant TherapyAdverse Event

Showing 15 of 600 indications

Posaconazole brand names and reporting trend

Posaconazole is sold under the brand name Noxafil Powdermix Kit.

Brand names

Noxafil Powdermix Kit12,226

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking posaconazole with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.