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Ponesimod Side Effects

The most commonly reported side effects of ponesimod include product dose omission issue, fatigue, and dyspnoea, based on 322 FDA adverse event reports from 2020 to 2025. 3.1% of reports found the drug to be ineffective.

Ponesimod side effects

Percentages show how often each reaction appears relative to total reports for ponesimod.

1
Product Dose Omission Issue12.7%41
2
Fatigue7.5%24
3
Dyspnoea5.0%16
4
Dizziness5.0%16
5
Covid-194.0%13
6
Headache3.7%12
7
Hypoaesthesia3.1%10
8
Drug Ineffective3.1%10
9
Multiple Sclerosis Relapse2.8%9
10
Nausea2.8%9
11
Pain2.5%8
12
Therapy Interrupted2.5%8
13
Somnolence2.5%8
14
Hypersensitivity2.2%7
15
Multiple Sclerosis2.2%7

These are voluntary reports and do not establish that ponesimod caused these reactions.

Report severity

47.5%Serious153 reports
12.1%Hospitalizations39 reports
0.3%Fatal1 reports

Seriousness is determined by the reporter, not by OpenClaim.

Ponesimod drug interactions

Other drugs that appear in adverse event reports alongside ponesimod. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Ocrelizumab1.9%6
2
Teriflunomide1.6%5
3
Dimethyl1.2%4
4
Gabapentin1.2%4
5
Cladribine0.9%3
6
Monomethyl-fumarate0.6%2
7
Diroximel-fumarate0.6%2
8
Natalizumab0.6%2
9
Citalopram-hydrobromide0.6%2
10
Peginterferon0.6%2
11
Ozanimod0.6%2
12
Fingolimod0.6%2
13
Ofatumumab0.6%2
14
Abobotulinumtoxina0.6%2
15
Clonazepam0.3%1

Taken alongside

1
Ergocalciferol5.0%16
2
Gabapentin2.8%9
3
Baclofen2.8%9
4
Ascorbic-acid1.6%5
5
Cholecalciferol1.6%5
6
Escitalopram-oxalate1.6%5
7
Amlodipine1.2%4
8
Aspirin1.2%4
9
Citalopram-hydrobromide1.2%4
10
Lisinopril1.2%4
11
Duloxetine-hydrochloride1.2%4
12
Fluticasone1.2%4
13
Hydroxyzine1.2%4
14
Candesartan-cilexetil0.9%3
15
Buspirone-hydrochloride0.9%3

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports ponesimod side effects

62.4% of ponesimod adverse event reports involve female patients and 17.4% involve male patients. The largest age group is adult at 95%. These figures reflect who reports side effects, not underlying risk.

Sex

Female62.4%
Male17.4%
Unknown20.2%

Age group

< 20.0%
2–110.7%
12–170.0%
18–6494.6%
65+4.7%

What is ponesimod used for

Conditions and purposes for which patients were taking ponesimod when the adverse event was reported.

Accidental Exposure To ProductDemyelinationMultiple SclerosisMultiple SclerosisMultiple Sclerosis RelapseProduct Used For Unknown IndicationPrimary Progressive Multiple SclerosisProduct Used For Unknown IndicationRelapsing Multiple SclerosisRelapsing-remitting Multiple SclerosisRelapsing Multiple SclerosisRelapsing-remitting Multiple SclerosisSecondary Progressive Multiple Sclerosis

Ponesimod brand names and reporting trend

Ponesimod is sold under the brand name Ponvory.

Brand names

Ponvory99

Quarterly reports (20202025)

2020202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking ponesimod with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.