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Pomalidomide Side Effects

The most commonly reported side effects of pomalidomide include plasma cell myeloma, death, and fatigue, based on 99,303 FDA adverse event reports from 2009 to 2025. 2.1% of reports found the drug to be ineffective.

Pomalidomide side effects

Percentages show how often each reaction appears relative to total reports for pomalidomide.

1
Plasma Cell Myeloma7.9%7,893
2
Death7.5%7,469
3
Fatigue7.3%7,250
4
Pneumonia6.2%6,159
5
Off Label Use4.4%4,356
6
Diarrhoea3.8%3,770
7
White Blood Cell Count Decreased3.6%3,597
8
Neutropenia3.2%3,216
9
Rash3.0%2,951
10
Dyspnoea2.8%2,806
11
Neuropathy Peripheral2.6%2,610
12
Asthenia2.6%2,607
13
Constipation2.6%2,576
14
Nausea2.5%2,454
15
Dizziness2.2%2,191

These are voluntary reports and do not establish that pomalidomide caused these reactions.

Report severity

61.4%Serious61,009 reports
26.8%Hospitalizations26,615 reports
13.8%Fatal13,685 reports

Seriousness is determined by the reporter, not by OpenClaim.

Pomalidomide drug interactions

Other drugs that appear in adverse event reports alongside pomalidomide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Dexamethasone10.7%10,671
2
Lenalidomide5.7%5,654
3
Daratumumab3.7%3,685
4
Bortezomib3.1%3,116
5
Carfilzomib3.1%3,113
6
Ixazomib-citrate2.4%2,393
7
Cyclophosphamide1.8%1,793
8
Isatuximab-irfc1.6%1,552
9
Selinexor0.9%933
10
Elotuzumab0.9%872
11
Thalidomide0.9%871
12
Melphalan0.7%705
13
Doxorubicin-hydrochloride0.7%676
14
Etoposide0.4%419
15
Belantamab-mafodotin-blmf0.4%349

Taken alongside

1
Dexamethasone19.8%19,663
2
Acyclovir15.3%15,223
3
Aspirin13.2%13,154
4
Acetaminophen7.3%7,204
5
Ergocalciferol6.5%6,422
6
Gabapentin5.4%5,341
7
Omeprazole5.3%5,225
8
Ondansetron4.8%4,786
9
Amlodipine4.7%4,654
10
Furosemide4.4%4,418
11
Metoprolol4.4%4,397
12
Oxycodone4.2%4,215
13
Levothyroxine-sodium4.2%4,164
14
Calcium4.0%3,987
15
Pantoprazole-sodium3.9%3,846

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports pomalidomide side effects

46.6% of pomalidomide adverse event reports involve female patients and 49.9% involve male patients. The largest age group is elderly at 71%. These figures reflect who reports side effects, not underlying risk.

Sex

Female46.6%
Male49.9%
Unknown3.5%

Age group

< 2<0.1%
2–11<0.1%
12–17<0.1%
18–6428.9%
65+71.1%

What is pomalidomide used for

Conditions and purposes for which patients were taking pomalidomide when the adverse event was reported.

5q Minus SyndromeAbdominal PainAccidental Exposure To ProductAccidental PoisoningAccommodation DisorderAcidosisAcute Kidney InjuryAcute LeukaemiaAcute Lymphocytic LeukaemiaAcute Monocytic LeukaemiaAcute Myeloid LeukaemiaAcute Myeloid Leukaemia (in Remission)Acute Myeloid Leukaemia RecurrentAcute Myelomonocytic LeukaemiaAdjuvant Therapy

Showing 15 of 642 indications

Pomalidomide brand names and reporting trend

Pomalidomide is sold under the brand name Pomalyst.

Brand names

Pomalyst20,697

Quarterly reports (20092025)

20122016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking pomalidomide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.