OpenClaim

Polidocanol Side Effects

The most commonly reported side effects of polidocanol include deep vein thrombosis, no adverse event, and pain, based on 1,386 FDA adverse event reports from 2004 to 2025. 3.0% of reports found the drug to be ineffective.

Polidocanol side effects

Percentages show how often each reaction appears relative to total reports for polidocanol.

1
Deep Vein Thrombosis24.2%336
2
No Adverse Event6.7%93
3
Pain6.1%85
4
Pain In Extremity5.0%69
5
Product Quality Issue4.7%65
6
Wrong Technique In Product Usage Process4.5%62
7
Off Label Use4.0%56
8
Erythema3.8%52
9
Skin Discolouration3.6%50
10
Pruritus3.2%44
11
Rash3.0%42
12
Drug Ineffective3.0%42
13
Dizziness2.9%40
14
Swelling2.8%39
15
Peripheral Swelling2.8%39

These are voluntary reports and do not establish that polidocanol caused these reactions.

Report severity

34.6%Serious479 reports
11.3%Hospitalizations157 reports
1.6%Fatal22 reports

Seriousness is determined by the reporter, not by OpenClaim.

Polidocanol drug interactions

Other drugs that appear in adverse event reports alongside polidocanol. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Nivolumab1.3%18
2
Ipilimumab1.0%14
3
Ibuprofen0.6%9
4
Cetirizine-hydrochloride0.5%7
5
Fluticasone0.4%5
6
Propranolol-hydrochloride0.4%5
7
Calcium0.4%5
8
Betamethasone0.4%5
9
Diphenhydramine0.4%5
10
Tacrolimus0.3%4
11
Adalimumab0.3%4
12
Prednisone0.3%4
13
Aspirin0.3%4
14
Dupilumab0.3%4
15
Gemcitabine0.3%4

Taken alongside

1
Levothyroxine-sodium2.7%38
2
Aspirin2.5%34
3
Amlodipine1.7%23
4
Acetaminophen1.5%21
5
Omeprazole1.5%21
6
Atorvastatin-calcium1.5%21
7
Metoprolol1.4%20
8
Furosemide1.2%16
9
Ibuprofen1.1%15
10
Ergocalciferol1.1%15
11
Prednisolone1.1%15
12
Pantoprazole-sodium1.0%14
13
Loperamide-hydrochloride1.0%14
14
Lisinopril0.9%13
15
Hydrochlorothiazide0.9%13

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports polidocanol side effects

51.4% of polidocanol adverse event reports involve female patients and 16.4% involve male patients. The largest age group is adult at 57%. These figures reflect who reports side effects, not underlying risk.

Sex

Female51.4%
Male16.4%
Unknown32.3%

Age group

< 20.6%
2–110.9%
12–170.9%
18–6457.3%
65+40.2%

What is polidocanol used for

Conditions and purposes for which patients were taking polidocanol when the adverse event was reported.

Aneurysmal Bone CystAntiemetic Supportive CareChronic Kidney Disease-associated PruritusDeep Vein ThrombosisDermatitis AtopicDry SkinDuodenal Ulcer HaemorrhageErythemaErythema MultiformeEndovenous AblationGastrooesophageal Variceal Haemorrhage ProphylaxisGreat Saphenous Vein ClosureHaemorrhoidsHaemostasisHerpes Zoster

Showing 15 of 71 indications

Polidocanol brand names and reporting trend

Polidocanol is sold under the brand name Asclera.

Brand names

Asclera145

Quarterly reports (20042025)

200420202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking polidocanol with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.