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Polatuzumab Side Effects

The most commonly reported side effects of polatuzumab include disease progression, off label use, and death, based on 8,732 FDA adverse event reports from 2013 to 2025. 5.3% of reports found the drug to be ineffective.

Polatuzumab side effects

Percentages show how often each reaction appears relative to total reports for polatuzumab.

1
Disease Progression22.1%1,934
2
Off Label Use14.1%1,230
3
Death8.3%724
4
Neutropenia6.2%540
5
Covid-195.9%515
6
Anaemia5.7%498
7
Febrile Neutropenia5.4%470
8
Drug Ineffective5.3%460
9
Pyrexia5.0%440
10
Blood Lactate Dehydrogenase Increased4.7%414
11
Platelet Count Decreased4.6%404
12
Neutrophil Count Decreased4.4%385
13
White Blood Cell Count Decreased4.2%366
14
Cytokine Release Syndrome4.2%365
15
Thrombocytopenia4.1%359

These are voluntary reports and do not establish that polatuzumab caused these reactions.

Report severity

94.7%Serious8,271 reports
26.2%Hospitalizations2,292 reports
21.9%Fatal1,910 reports

Seriousness is determined by the reporter, not by OpenClaim.

Polatuzumab drug interactions

Other drugs that appear in adverse event reports alongside polatuzumab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Rituximab70.3%6,139
2
Cyclophosphamide48.9%4,266
3
Doxorubicin-hydrochloride44.8%3,913
4
Bendamustine-hydrochloride44.2%3,856
5
Prednisone35.3%3,084
6
Vincristine-sulfate31.6%2,757
7
Dexamethasone19.3%1,686
8
Etoposide15.1%1,315
9
Cisplatin14.9%1,305
10
Cytarabine14.9%1,298
11
Gemcitabine14.1%1,234
12
Prednisolone11.6%1,009
13
Oxaliplatin11.1%972
14
Ifosfamide10.4%906
15
Carboplatin8.7%758

Taken alongside

1
Acyclovir11.3%985
2
Acetaminophen7.9%690
3
Rituximab7.8%679
4
Dexamethasone7.2%632
5
Bendamustine-hydrochloride6.7%582
6
Allopurinol6.0%520
7
Cyclophosphamide5.6%489
8
Sulfamethoxazole5.3%462
9
Ondansetron5.2%455
10
Prednisone4.8%421
11
Doxorubicin-hydrochloride4.6%405
12
Omeprazole4.6%401
13
Trimethoprim3.9%340
14
Pantoprazole-sodium3.8%336
15
Filgrastim3.6%310

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports polatuzumab side effects

33.0% of polatuzumab adverse event reports involve female patients and 46.6% involve male patients. The largest age group is elderly at 58%. These figures reflect who reports side effects, not underlying risk.

Sex

Female33.0%
Male46.6%
Unknown20.4%

Age group

< 2<0.1%
2–11<0.1%
12–170.1%
18–6441.4%
65+58.3%

What is polatuzumab used for

Conditions and purposes for which patients were taking polatuzumab when the adverse event was reported.

Adult T-cell Lymphoma/leukaemia RefractoryAgranulocytosisAdenocarcinoma PancreasAdult T-cell Lymphoma/leukaemia RecurrentAdverse Drug ReactionB-cell LymphomaB-cell Lymphoma RecurrentB-cell Lymphoma RefractoryB-cell LymphomaB-cell Lymphoma RecurrentB-cell Lymphoma RefractoryB-cell Lymphoma Stage IB-cell Lymphoma Stage IvBlood DisorderBreast Cancer

Showing 15 of 121 indications

Polatuzumab brand names and reporting trend

Polatuzumab is sold under the brand name Polivy.

Brand names

Polivy7,510

Quarterly reports (20132025)

20132016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking polatuzumab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.