OpenClaim

Podofilox Side Effects

The most commonly reported side effects of podofilox include pain, anxiety, and application site pain, based on 124 FDA adverse event reports from 2004 to 2025. 11.3% of reports found the drug to be ineffective.

Podofilox side effects

Percentages show how often each reaction appears relative to total reports for podofilox.

1
Pain13.7%17
2
Drug Ineffective11.3%14
3
Anxiety10.5%13
4
Application Site Pain8.9%11
5
Emotional Distress8.9%11
6
Off Label Use8.9%11
7
Anhedonia8.1%10
8
Tremor6.5%8
9
Chronic Kidney Disease6.5%8
10
Hypersensitivity5.6%7
11
Drug Interaction5.6%7
12
Dyspnoea5.6%7
13
Acute Kidney Injury5.6%7
14
Depression4.8%6
15
Renal Failure4.8%6

These are voluntary reports and do not establish that podofilox caused these reactions.

Report severity

48.4%Serious60 reports
19.4%Hospitalizations24 reports
2.4%Fatal3 reports

Seriousness is determined by the reporter, not by OpenClaim.

Podofilox drug interactions

Other drugs that appear in adverse event reports alongside podofilox. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Tenofovir10.5%13
2
Emtricitabine6.5%8
3
Ritonavir5.6%7
4
Lopinavir4.8%6
5
Adalimumab4.8%6
6
Efavirenz4.0%5
7
Insulin3.2%4
8
Diazepam2.4%3
9
Cyclobenzaprine-hydrochloride2.4%3
10
Fentanyl2.4%3
11
Imiquimod2.4%3
12
Azathioprine2.4%3
13
Lisinopril2.4%3
14
Atorvastatin-calcium2.4%3
15
Ibuprofen2.4%3

Taken alongside

1
Acetaminophen19.4%24
2
Prednisone17.7%22
3
Gabapentin15.3%19
4
Cetirizine-hydrochloride15.3%19
5
Albuterol14.5%18
6
Atorvastatin-calcium12.9%16
7
Imiquimod12.9%16
8
Azithromycin12.9%16
9
Potassium-chloride12.1%15
10
Lisinopril11.3%14
11
Emtricitabine11.3%14
12
Tenofovir11.3%14
13
Omeprazole11.3%14
14
Aspirin11.3%14
15
Amlodipine11.3%14

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports podofilox side effects

28.2% of podofilox adverse event reports involve female patients and 60.5% involve male patients. The largest age group is adult at 83%. These figures reflect who reports side effects, not underlying risk.

Sex

Female28.2%
Male60.5%
Unknown11.3%

Age group

< 20.0%
2–114.8%
12–171.2%
18–6483.3%
65+10.7%

What is podofilox used for

Conditions and purposes for which patients were taking podofilox when the adverse event was reported.

Accidental ExposureAcrochordonAnogenital WartsAnogenital WartsFoot DeformityHerpes ZosterLymphangiomaMolluscum ContagiosumMolluscum ContagiosumPapilloma Viral InfectionProduct Used For Unknown IndicationPruritusPruritus GenitalProduct Used For Unknown IndicationRheumatoid Arthritis

Showing 15 of 20 indications

Podofilox brand names and reporting trend

Podofilox is sold under the brand name Podofilox.

Brand names

Podofilox81

Quarterly reports (20042025)

200420202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking podofilox with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.