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Pivmecillinam Side Effects

The most commonly reported side effects of pivmecillinam include malaise, confusional state, and acute kidney injury, based on 297 FDA adverse event reports from 2004 to 2025.

Pivmecillinam side effects

Percentages show how often each reaction appears relative to total reports for pivmecillinam.

1
Malaise6.7%20
2
Confusional State6.4%19
3
Acute Kidney Injury5.7%17
4
Diarrhoea4.7%14
5
Constipation4.4%13
6
Urinary Incontinence4.4%13
7
Drug Interaction4.0%12
8
Decreased Appetite4.0%12
9
Foetal Exposure During Pregnancy3.7%11
10
Rash3.7%11
11
Headache3.4%10
12
Hyponatraemia3.4%10
13
Tubulointerstitial Nephritis3.4%10
14
Abdominal Pain3.0%9
15
Pain3.0%9

These are voluntary reports and do not establish that pivmecillinam caused these reactions.

Report severity

99.3%Serious295 reports
54.9%Hospitalizations163 reports
10.4%Fatal31 reports

Seriousness is determined by the reporter, not by OpenClaim.

Pivmecillinam drug interactions

Other drugs that appear in adverse event reports alongside pivmecillinam. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Trimethoprim10.1%30
2
Nitrofurantoin6.7%20
3
Acetaminophen5.4%16
4
Furosemide4.7%14
5
Ciprofloxacin4.4%13
6
Omeprazole4.0%12
7
Tramadol-hydrochloride4.0%12
8
Donepezil-hydrochloride3.4%10
9
Diclofenac3.0%9
10
Venlafaxine3.0%9
11
Amoxicillin3.0%9
12
Sulfamethoxazole2.7%8
13
Fluoxetine-hydrochloride2.7%8
14
Prednisolone2.4%7
15
Warfarin2.4%7

Taken alongside

1
Acetaminophen29.3%87
2
Nitrofurantoin19.9%59
3
Atorvastatin-calcium17.2%51
4
Levothyroxine-sodium13.5%40
5
Furosemide12.1%36
6
Omeprazole11.8%35
7
Amoxicillin10.8%32
8
Bisoprolol-fumarate10.8%32
9
Trimethoprim9.8%29
10
Amlodipine9.4%28
11
Albuterol8.1%24
12
Eszopiclone7.7%23
13
Pantoprazole-sodium7.4%22
14
Hydrocortisone7.4%22
15
Prednisolone6.7%20

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports pivmecillinam side effects

71.7% of pivmecillinam adverse event reports involve female patients and 20.9% involve male patients. The largest age group is elderly at 70%. These figures reflect who reports side effects, not underlying risk.

Sex

Female71.7%
Male20.9%
Unknown7.4%

Age group

< 22.4%
2–110.0%
12–170.0%
18–6427.8%
65+69.8%

What is pivmecillinam used for

Conditions and purposes for which patients were taking pivmecillinam when the adverse event was reported.

Antibiotic TherapyBacteriuriaCystitisCystitisDiarrhoeaDrug Use For Unknown IndicationEscherichia InfectionEscherichia BacteraemiaHaematuriaIll-defined DisorderInfectionIll-defined DisorderMedication ErrorPainPeritonitis

Showing 15 of 27 indications

Pivmecillinam brand names and reporting trend

Pivmecillinam is sold under the brand name Pivya.

Brand names

Pivya303

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking pivmecillinam with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.