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Pirtobrutinib Side Effects

The most commonly reported side effects of pirtobrutinib include death, malignant neoplasm progression, and pneumonia, based on 590 FDA adverse event reports from 2022 to 2025. 4.2% of reports found the drug to be ineffective.

Pirtobrutinib side effects

Percentages show how often each reaction appears relative to total reports for pirtobrutinib.

1
Death13.6%80
2
Malignant Neoplasm Progression10.5%62
3
Pneumonia8.5%50
4
Disease Progression7.6%45
5
Chronic Lymphocytic Leukaemia5.9%35
6
Off Label Use5.3%31
7
Anaemia5.3%31
8
Pancytopenia4.7%28
9
Lymphadenopathy4.2%25
10
Drug Ineffective4.2%25
11
White Blood Cell Count Increased3.7%22
12
Covid-193.6%21
13
Cytokine Release Syndrome3.6%21
14
Splenomegaly3.6%21
15
Platelet Count Decreased3.4%20

These are voluntary reports and do not establish that pirtobrutinib caused these reactions.

Report severity

76.9%Serious454 reports
33.9%Hospitalizations200 reports
28.8%Fatal170 reports

Seriousness is determined by the reporter, not by OpenClaim.

Pirtobrutinib drug interactions

Other drugs that appear in adverse event reports alongside pirtobrutinib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Rituximab24.2%143
2
Venetoclax19.5%115
3
Ibrutinib8.3%49
4
Bendamustine-hydrochloride8.1%48
5
Doxorubicin-hydrochloride5.8%34
6
Cyclophosphamide5.6%33
7
Vincristine-sulfate5.3%31
8
Fludarabine-phosphate4.4%26
9
Prednisone4.2%25
10
Idelalisib4.1%24
11
Zanubrutinib3.9%23
12
Acalabrutinib3.6%21
13
Lenalidomide3.2%19
14
Obinutuzumab3.1%18
15
Etoposide2.9%17

Taken alongside

1
Acyclovir14.7%87
2
Allopurinol7.1%42
3
Pantoprazole-sodium3.9%23
4
Sulfamethoxazole3.7%22
5
Atorvastatin-calcium3.7%22
6
Trimethoprim3.6%21
7
Acetaminophen3.1%18
8
Metformin2.9%17
9
Aspirin2.4%14
10
Furosemide2.4%14
11
Bisoprolol-fumarate2.4%14
12
Venetoclax2.2%13
13
Dexamethasone2.0%12
14
Bendamustine-hydrochloride2.0%12
15
Omeprazole2.0%12

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports pirtobrutinib side effects

25.8% of pirtobrutinib adverse event reports involve female patients and 51.9% involve male patients. The largest age group is elderly at 72%. These figures reflect who reports side effects, not underlying risk.

Sex

Female25.8%
Male51.9%
Unknown22.4%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6427.9%
65+72.1%

What is pirtobrutinib used for

Conditions and purposes for which patients were taking pirtobrutinib when the adverse event was reported.

B-cell LymphomaB-cell Small Lymphocytic LymphomaBreast CancerBurkitt^s Lymphoma Stage IiiCarcinoid TumourChronic LeukaemiaChronic Lymphocytic LeukaemiaChronic Lymphocytic Leukaemia RecurrentChronic Lymphocytic Leukaemia RefractoryDiffuse Large B-cell LymphomaFollicular LymphomaHaematological MalignancyHypogammaglobulinaemiaIll-defined DisorderLeukaemia

Showing 15 of 29 indications

Pirtobrutinib brand names and reporting trend

Pirtobrutinib is sold under the brand name Jaypirca.

Brand names

Jaypirca283

Quarterly reports (20222025)

202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking pirtobrutinib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.