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Piroxicam Side Effects

The most commonly reported side effects of piroxicam include drug hypersensitivity, rash, and arthralgia, based on 8,471 FDA adverse event reports from 2004 to 2025. 10.2% of reports found the drug to be ineffective.

Piroxicam side effects

Percentages show how often each reaction appears relative to total reports for piroxicam.

1
Drug Hypersensitivity14.1%1,195
2
Rash10.5%893
3
Arthralgia10.5%887
4
Drug Ineffective10.2%866
5
Condition Aggravated10.2%861
6
Pain9.8%833
7
Fatigue9.8%830
8
Rheumatoid Arthritis9.7%825
9
Diarrhoea9.7%819
10
Psoriatic Arthropathy9.5%801
11
Nausea9.3%788
12
Sinusitis9.3%785
13
Off Label Use9.1%774
14
Sciatica8.7%737
15
Headache8.3%705

These are voluntary reports and do not establish that piroxicam caused these reactions.

Report severity

80.1%Serious6,786 reports
38.3%Hospitalizations3,243 reports
14.0%Fatal1,187 reports

Seriousness is determined by the reporter, not by OpenClaim.

Piroxicam drug interactions

Other drugs that appear in adverse event reports alongside piroxicam. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Adalimumab17.3%1,465
2
Etanercept15.6%1,318
3
Methotrexate14.7%1,242
4
Infliximab13.8%1,172
5
Abatacept13.7%1,157
6
Pregabalin12.8%1,087
7
Rituximab12.7%1,078
8
Leflunomide12.6%1,068
9
Tocilizumab12.5%1,059
10
Diclofenac12.3%1,045
11
Hydroxychloroquine-sulfate12.3%1,045
12
Golimumab12.3%1,044
13
Sulfasalazine12.3%1,038
14
Acetaminophen11.7%988
15
Mycophenolate11.2%948

Taken alongside

1
Acetaminophen22.4%1,897
2
Ergocalciferol16.9%1,433
3
Levothyroxine-sodium16.7%1,412
4
Lisinopril15.2%1,286
5
Ibuprofen13.6%1,152
6
Pantoprazole-sodium12.5%1,055
7
Meloxicam11.5%977
8
Prednisone11.2%950
9
Lorazepam11.0%936
10
Lansoprazole10.9%927
11
Albuterol10.6%895
12
Omeprazole10.5%892
13
Prednisolone10.5%889
14
Aspirin10.1%858
15
Sulfasalazine10.0%846

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports piroxicam side effects

64.1% of piroxicam adverse event reports involve female patients and 26.9% involve male patients. The largest age group is adult at 65%. These figures reflect who reports side effects, not underlying risk.

Sex

Female64.1%
Male26.9%
Unknown9.0%

Age group

< 20.2%
2–111.0%
12–171.0%
18–6464.7%
65+33.2%

What is piroxicam used for

Conditions and purposes for which patients were taking piroxicam when the adverse event was reported.

Abdominal PainAbdominal Pain UpperAffective DisorderAlkaptonuriaAllergy TestAnalgesiaAnalgesic EffectAnalgesic Intervention Supportive TherapyAnalgesic TherapyAngina PectorisAnkylosing SpondylitisAntidepressant TherapyAntiinflammatory TherapyAnxietyAnxiety Disorder

Showing 15 of 327 indications

Piroxicam brand names and reporting trend

Piroxicam is sold under the brand name Feldene.

Brand names

Feldene7,202

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking piroxicam with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.